RESUMO
Ovariohysterectomy and ovariectomy are commonly used to control the pet population and the health and behavioralbenefits of dogs and cats. The aim of this study was to evaluate the inherent and humoral immune factors followingovariohysterectomy and ovariectomy surgery in female dogs. In this study, 18 female dogs were used. After anesthesia,animals received one of the following three treatments randomly: 1- laparotomy (control group) 2- ovariohysterectomy 3-ovariectomy. The intrinsic and humoral immunity at baseline, 7, 14, 30 and 60 days after surgery were evaluated. In thecontrol group, up to the 7th day of the study, serum myeloperoxidase and bactericidal activity increased, lysozyme andcomplement activity decreased, and constant antitrypsin activity was observed. Ovariohysterectomy and / or ovariectomyhave led to a change in the pattern of variation in the experimental group. Except for antitrypsin, the change in the otherfactors compared to the control group was milder or less; there was a significant difference in the activity of thecomplement, myeloperoxidase and lysozyme activity compared to the control group. The total amount of immunoglobulins inthe blood, the level of anti-salmonella antigen and anti-sheep red blood cell antibody in the experimental groups wasdecreased in comparison to the control on day 7. Although ovariohysterectomy and ovariectomy resulted in a weakerimmune response than the control group, there was no significant difference between the two groups.