Concordance for curve type in idiopathic scoliosis among family members / Concordância do tipo de curva em escoliose idiopática entre familiares

ABSTRACT OBJECTIVE: To evaluate the concordance for the curve pattern, side and levels of the superior apical vertebrae, apex and inferior apical vertebrae of curves in patients and their relatives with idiopathic scoliosis. METHODS: Concordance according to the Lenke classification for curve pattern, side and levels of the superior apical vertebrae, apex and inferior apical vertebrae were evaluated comparative and prospectively in 243 pairs of patients and respective relatives with idiopathic scoliosis. RESULTS: The family concordance for the curve pattern and side was 51.4% (125 pairs). Among these pairs, the concordance of the levels of the vertebrae was 91.2% (114 pairs). The concordance rate for the curve pattern and side between parents/children was 51.6% and between siblings was 50.0% (p-value= 0.411). The concordance rates of the levels of vertebrae were 86.8% and 95.1%, respectively (p-value = 0.219). CONCLUSION: Curve shape in idiopathic scoliosis is related to family and degree of kinship, since the data showed a high concordance for the curve pattern, side and levels of the apical vertebrae and apex between patients and relatives with this deformity. The concordance was higher in those with a closer degree of kinship. Level of Evidence II, Lesser Quality Prospective Study.

RESUMO OBJETIVO: Avaliar a concordância para o padrão de curva, lado e níveis das vértebras apical superior, ápex e apical inferior das curvas de pacientes e respectivos familiares com escoliose idiopática. MÉTODOS: A concordância, pela classificação de Lenke, para o padrão de curva, lado e níveis das vértebras apical superior, ápex e apical inferior foi avaliada em 243 pares de pacientes e respectivos familiares com escoliose idiopática. RESULTADOS: A concordância familiar para o padrão de curva e lado foi de 51,4% (125 pares). Entre esses pares, a concordância dos níveis das vértebras foi de 91,2% (114 pares). A taxa de concordância para o padrão de curva e lado entre pais/filhos foi de 51,6% e entre irmãos foi de 50,0% (p= 0,411). As taxas de concordância dos níveis das vértebras foram respectivamente de 86,8% e 95,1% (p-valor = 0,219). CONCLUSÃO: O formato das curvas na escoliose idiopática tem relação familiar e com o grau de parentesco, uma vez que se reportou alta concordância para o padrão de curva, lado e níveis das vértebras apicais e ápex entre pacientes e familiares com a deformidade. A concordância foi maior entre aqueles com grau de parentesco mais próximo. Nível de Evidência Ii, Estudo Prospectivo de Menor Qualidade.

A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

PURPOSE: To assess the histological response of damaged osteochondral tissue in the femoral condyles of rabbits after repairing the wounds with sugar cane biopolymer gel - compared to the control group. METHODS: The study investigated 16 New Zealand rabbits, at 90, 120 and 180 days after surgery. In all the animals, a lesion of 3.2 mm in diameter and 4 mm deep was induced in each right and left femoral condyle. Each animal has provided both knees, divided into medial and lateral condyle, resulting in 64 samples. 32 knees were divided into two groups: Right knee, medial and lateral condyles, filled with biopolymer; Left knee, medial and lateral condyles, unfilled. The anatomical specimens were removed, and subjected to histological techniques and morphometric and statistical analysis. RESULTS: In all the periods of the group under study an inflammatory reaction mediated by giant cells and mononuclear cells was found, while in the control group there was early healing produced by fibroblasts and few mononuclear cells with statistical significance between groups. CONCLUSION: The biopolymer gel caused an inflammatory reaction mediated by giant cells and mononuclear cells while the control group there was cicatrization mediated by fibroblasts.