Acute renal failure and bilateral kidney infiltration as the first presentation of non-Hodgkin lymphoma

Diffuse bilateral infiltration of the kidneys by lymphoma is probably the rarest cause of renal insufficiency. Moreover, acute renal failure as the initial manifestation of the lymphoma is reported only in a few cases. A 44-year-old man complaining of bilateral flank pain and weakness for 2 months was admitted with acute renal failure. Ultraonography revealed hyperechoic bilaterally enlarged kidneys and an enlarged spleen. Fat pad aspiration was negative for amyloidosis and serum protein electrophoresis was normal. Needle biopsy of the kidney and pathologic examination showed diffuse infiltration of the interstitium with lymphocytes and atypical cells. Bone marrow aspiration and biopsy were negative for malignant cells. Open kidney biopsy was performed and infiltrated cells positive for CD20 and negative for CD3 markers were observed based upon which diagnosis of diffuse large B-cell type non-Hodgkin lymphoma was made

Incidence of end-stage renal disease in Guilan province, Iran, 2005 to 2007

We reviewed records of patients with ESRD in all dialysis and kidney transplant centers of Guilan province to determine the incidence and modalities for treatment of ESRD from 2005 to 2007. Records of 759 patients were reviewed during the 3-year period of the study. The male-female ratio was 1.34:1 and the men age at the time of diagnosis was 56.3 +/- 16.8 years. The most frequent age group was 60 years and older [45.8%]. The incidence ESRD during 2005,2006, and 2007 were 100.36 pmp 100,60 pmp and 110.66 pmp, respectively. The most common causes of ESRD were hypertension [29.4%], unknown [26.6%], and diabetes mellitus [17.9%]. The most common modality at initiation of renal replacement therapy was hemodialysis [96.0%]. The entrance rate of hemodialysis in 2005, 2006, and 2007 were 29.6%, 35.0%, and 35.4%, and the discontinuing rate of hemodialysis in these years were 29.5%, 32.1%, and 38.4%, respectively