Evaluation of antibacterial activity of macrocyclic metal complexes derived from dihydrazone and diketone.

Synthesis of macrocyclic metal complexes of Cr(III) and Fe(III) by the condensation of benzil dihydrazone with 1H-indole-2, 3-dione.The metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility, thermal analysis, ESR, infrared, 1H NMR and UV-visible spectroscopy. On the bases of these studies, a five-coordinate square pyramidal geometry is proposed for all the metal complexes. In vitro antibacterial activity of macrocyclic metal complexes exhibited good results.

Evidence Based Approach to Perthes.

Perthes is a self-limiting disorder of paediatric hip. The outcome of this disorder is variable. Every aspect of it including, etiology, pathogenesis, pathology, classification, natural course, management and outcome is controversial. There is still no clear guideline for the management of Perthes disease. The aim of treatment is to prevent the head deformity and subsequent secondary osteoarthritis of hip. To maximize the results of containment procedures, measures to unstiffen the hip should be taken. Evidences are there that only a section of involved hips need intervention. Most untreated hips do not require intervention until the age of forty.

MicroRNAs and Their Role in Bone Remodeling and Pathogenesis.

MicroRNAs, a class of post-transcriptional gene expression regulators that bind to complementary sequences in the 3’ UTR or 5’ UTR of mRNAs have recently been detected in human body fluids including peripheral blood plasma as extracellular nuclease resistant entities. It is now clear that the biogenesis and functions of microRNAs are related to the molecular mechanisms of various clinical diseases and they can potentially regulate every aspect of cellular activity. This review will highlight our current understanding of microRNA biogenesis and their mechanisms of action. It will also summarize recent works on the role of microRNAs in bone remodeling including angiogenesis, osteoblast and osteoclast differentiation and in various bone related pathologies. An in-depth understanding of the roles of these regulatory mRNAs in the skeleton will be critical for the development of new therapeutics aimed on bone remodeling including fracture repair and bone-related diseases.

Screening for hepatocellular carcinoma

Liver cancer remains one of the most common causes of cancer death globally, and its cure rate has not improved for the past 20 years. Hepatocellular carcinoma develops in patients with cirrhosis of any etiology. Patients with cirrhosis are thus usually included in screening program aiming to achieve early detection and effective treatment for HCC. Only those patients diagnosed with HCC who would benefit with the available treatment, should undergo the screening procedure. This is based on ultrasonography and alpha-fetoprotein every 3-6 months based on the prevalence and economic status of the community being tested