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1.
The Korean Journal of Parasitology ; : 379-383, 2015.
Artigo em Inglês | WPRIM | ID: wpr-50467

RESUMO

Visceral leishmaniasis (VL) or kala-azar mainly affects children in endemic areas. This study was conducted to determine the seroprevalence of VL using direct agglutination test (DAT) in children living in rural districts of Alborz Province located 30 km from Tehran capital city of Iran. Multi-stage cluster random sampling was applied. Blood samples were randomly collected from 1,007 children under 10 years of age in the clusters. A total of 37 (3.7%) of the studied population showed anti-Leishmania infantum antibodies with titers of > or =1:800. There was a significant association between positive sera and various parts of the rural areas of Alborz Province (P or =1:3,200 indicated kala-azar clinical features and treated with anti-leishmaniasis drugs in pediatric hospital. The findings of this study indicated that Leishmania infection is prevalent in rural areas of Alborz Province. Therefore, it is necessary to increase the awareness and alertness among physicians and public health managers, particularly in high-risk rural areas of the province in Iran.


Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Masculino , Anticorpos Antiprotozoários/sangue , Política de Saúde , Irã (Geográfico)/epidemiologia , Leishmania infantum/imunologia , Leishmaniose Visceral/sangue , Saúde da População Rural , Estudos Soroepidemiológicos
2.
Pakistan Journal of Medical Sciences. 2009; 25 (1): 103-107
em Inglês | IMEMR | ID: emr-92383

RESUMO

To compare cord bacterial colonization and cord separation time among newborns whose cords were treated with Alcohol 70% versus dry cord care. The participating neonates in the two hospitals affiliated to Shaheed Beheshti University of Medical Sciences of Iran were randomly assigned to two groups. Group 1, had 36 neonates and Group had 41 neonates, who were treated with dry cord care and Alcohol 70% methods respectively. In the dry cord care group infant were significantly colonized with group B Streptococcus [58.3% vs 35% p=0.042], Staphylococcus epidermidis [86.7% vs 61% p=0.020] and Escherichio coil [88.9% vs 67.5% p=0.025]. There were no cases of local umbilical infection in either group. There was no significant correlation between separation time of umbilical cord and the two methods of the care. Based on the present study, bacterial colonization was higher in dry cord care group. There is, therefore, potential risk in discontinuing bacterial treatment of the umbilical cord stump


Assuntos
Humanos , Etanol , Recém-Nascido , Infecções Bacterianas/complicações , Infecções Bacterianas , Cordão Umbilical/microbiologia
3.
The Korean Journal of Parasitology ; : 59-63, 2007.
Artigo em Inglês | WPRIM | ID: wpr-131774

RESUMO

Merozoite surface protein-1 (MSP-1) and merozoite surface protein-2 (MSP-2) were used to develop vaccines and to investigate the genetic diversity in Plasmodium falciparum malaria in Iran. Nested polymerase chain reaction amplification was used to determine polymorphisms of block 2 of the MSP-1 and the central domain of MSP-2 genes. A total of 67 microscopically positive P. falciparum infected individuals from a major endemic region, southeast Iran, were included in this trial. Nine alleles of MSP-1 and 11 alleles of MSP-2 were identified. The results showed that amplified product from these surface antigen genes varied in size and there was specific pattern for each isolate. Besides, regarding this pattern, 23 multiple infections with at least 2 alleles were observed. While the endemic regions of malaria in Iran is classified in low to moderate group, but extensive polymorphism was observed for each marker and the MSP-2 central repeat was the most diverse that could be considered in designing malaria vaccine.


Assuntos
Adolescente , Adulto , Animais , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Antígenos de Protozoários/genética , Doenças Endêmicas , Variação Genética , Irã (Geográfico)/epidemiologia , Malária Falciparum/epidemiologia , Proteína 1 de Superfície de Merozoito/genética , Plasmodium falciparum/genética , Reação em Cadeia da Polimerase/métodos , Polimorfismo Genético , Proteínas de Protozoários/genética
4.
The Korean Journal of Parasitology ; : 59-63, 2007.
Artigo em Inglês | WPRIM | ID: wpr-131771

RESUMO

Merozoite surface protein-1 (MSP-1) and merozoite surface protein-2 (MSP-2) were used to develop vaccines and to investigate the genetic diversity in Plasmodium falciparum malaria in Iran. Nested polymerase chain reaction amplification was used to determine polymorphisms of block 2 of the MSP-1 and the central domain of MSP-2 genes. A total of 67 microscopically positive P. falciparum infected individuals from a major endemic region, southeast Iran, were included in this trial. Nine alleles of MSP-1 and 11 alleles of MSP-2 were identified. The results showed that amplified product from these surface antigen genes varied in size and there was specific pattern for each isolate. Besides, regarding this pattern, 23 multiple infections with at least 2 alleles were observed. While the endemic regions of malaria in Iran is classified in low to moderate group, but extensive polymorphism was observed for each marker and the MSP-2 central repeat was the most diverse that could be considered in designing malaria vaccine.


Assuntos
Adolescente , Adulto , Animais , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Antígenos de Protozoários/genética , Doenças Endêmicas , Variação Genética , Irã (Geográfico)/epidemiologia , Malária Falciparum/epidemiologia , Proteína 1 de Superfície de Merozoito/genética , Plasmodium falciparum/genética , Reação em Cadeia da Polimerase/métodos , Polimorfismo Genético , Proteínas de Protozoários/genética
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