RESUMO
Objective: To compare risk factors and progression free survival of Type-1 and II endometrial cancers
Methods: A retrospective analysis of 149 patients with early stage endometrial carcinoma treated between 1997 and 2012 in Aga Khan University Hospital, Karachi was performed
Results: A total of 149 patients were analyzed. Type-l tumors accounted for 92% of cases in the study while 8% wereType-ll tumors. The mean age, BMI, parity, co-morbidities [hypertension and Diabetes], family history and history of polycystic disease were comparable in both groups. Overall better survival [113 Vs 24 months] was observed for Type-l endometrial cancer
Conclusion: Both types of endometrial cancer may share common etiologic factors. Despite the limitation of small numbers in one group this study confirms better survival in Type-l endometrial cancer
RESUMO
To compare perioperative morbidity and survival data between patients with early-stage endometrial cancer who did or did not undergo selective lymphadenectomy. Retrospective analysis of 180 patients with early-stage endometrial carcinoma treated between 1999 and 2008 was performed in Aga Khan University Hospital, Karachi, Pakistan. Data from 180 patients were analysed. The selective lymphadenectomy group contained 108 women [60%] and the no lymphadenectomy group contained 72 women [40%]. The median number of lymph nodes removed was 9. The mean age and extent of disease, as assessed by staging, tumour size, myometrial invasion, and lymphovascular invasion were comparable between groups. Upstaging of the disease to stage 3 and 4 occurred in 11% of patients in the lymphadenectomy group. There were no significant differences in the medical or surgical complications between groups. At a median follow-up of 26 months, both groups had comparable survival [lymphadenectomy versus no lymphadenectomy: 34 versus 32 months]. Similar survival was noted for patients who underwent the removal of more or less than 5 pelvic lymph nodes. Selective lymphadenectomy offers the advantage of improved surgical staging but no therapeutic benefit in terms of overall survival
RESUMO
A hospital based observational study was carried out on pregnant women presenting with either acute hepatitis or fulminant hepatic failure [FHF], during the past years. Of 53 patients, 20 [38%] developed FHF.Non-A, Non-B was the commonest cause [62%] followed by hepatitis B in 17% and hepatitis A in 4% cases. Eight women expired [case fatality rate 15%] with a high maternal mortality [62%] caused by NANB hepatitis. Perinatal mortality was 30%. Poor prognostic factors identified were lack of antenatal care, severity of jaundice, history of somnolence, gastrointestinal bleeding and a high grade of encephalopathy