RESUMO
Introduction: Chemokines glycoproteins with potent leukocyte activation and/or chemotactic activity. Chemokines mediate their effects via interaction with specific chemokine receptors expressed on a wide range of cell types. The CXC subfamily of chemokines shares a common structure of a single amino acid separating the two amino terminal cysteine residues [C1, C2]. Chemokines have been implicated as inflammatory mediators in a wide range of pathologies on the basis of studies using clinical material and animal disease models. Most patients with type 1 diabetes are considered to have T-cell-mediated autoimmune disease. A clinically applicable method of measuring pancreatic beta-cell-specific T-cell function in cases of type 1 diabetes has yet to be established: Interferon-inducible protein-10 [IP-10] is a chemokine that promotes the migration of activated T cells [T helper 1 [Th1] lymphocytes], and a correlation has been reported between the level of this chemokine and disease activity in cases of chronic active hepatitis in humans
Aim of the work: To evaluate whether measurement of serum IP-10 concentration is useful in disease prediction and estimation of the immune mediated beta-cel/ destruction in cases of type 1 diabetes
Material and methods: 34 TYPE 1 DM patients 12 newly diagnosed and 22 with established disease as well as 15 controls were studied. Fasting blood glucose, serum c-peptide, autoantibodies IA-2, IP-10, and beta-interferon [IFN-beta] were measured after overnight fasting
Results: The serum concentration of IP-10 is significantly elevated in cases of autoimmune diabetes [Ab+ type 1]. A significantpositive linear correlation between serum IP-10 and IFN-beta levels was observed only in autoimmune diabetes subjects [Ab+ type 1] and not in Ab-ve patients or the controls. There was a significant negative correlation between serum IP-10 and both the duration of diabetes and age of the patients in Ab+ve TYPE 1 DM patients
Conclusion: Measurement of serum IP-10 concentration in patients with autoimmune-related type 1 diabetes is a useful marker in predicting the onset of insulitis