Haematologial manifestations in HCV infected patients at Sharkia Governerate, Egypt

The aim of this study was to evaluate the hematological manifestations occurring in patients suffering from chronic hepatitis C virus [HCV] infection. Positive HCV-RNA cases [109] were subjected to complete blood count [CBC], prothrombin time [PT], partial thromboplastin time [PTT], bleeding time [BT], coagulation time [CT], detection of fibrinogen degradation products [FDPs], measurement of plasma alpha- antitrypsin [AAT], then bone marrow [BM] aspiration and examination for 20 cases. The patients were classified into three groups according to the histopathological staging and grading of liver biopsy. The comparison between groups according to histopathological grading and staging for hematological and chemical parameters revealed a significant statistical difference in platelets count, S albumin, ALT and AST levels. The comparison between groups according to histopathological grading and staging for coagulation profile, AAT level and FDPs revealed a significant statistical difference between all parameters. Bone marrow aspiration and examination revealed mild hypocellularity with an increased number of lymphocytes and a relevance of plasmacytoid-lymphocytes

Autoantibodies in HCV infected patients at Sharkia Governerate, Egypt

The aim of this study was to evaluate some immunological manifestations in chronic hepatitis C patients and to find out its relationship with liver pathology. The study included 109 positive HCV-RNA patients classified according to liver histopathology into three groups: Group I included 22 patients [G1S1], group II included 67 patients [G2S2] and group III included 20 patients [G3S3], where G = the degree of necro-inflammatory process and S = the stage of liver fibrosis. All patients were investigated for the presence of cryoglobulin, antineutrophil cytoplasmic [ANCA], anti-liver kidney microsomes [LKM], anti-double stranded DNA, [ds-DNA], anti-nuclear [ANA], anti-mitochondrial [AMA] and anti-smooth muscle [ASMA] autoantibodies. The high prevalence of autoantibodies in chronic HCV patients suggests that HCV may trigger an autoimmune reaction, but most probably do not indicate a distinct autoimmune mechanism. Cryoglobulins and ANCA may be considered as useful prognostic indicator for the increased risk of cirrhosis in chronic HCV patients. Follow up studies were recommended

validity of Ag-NOrs profile in some epithelial ovarian tumors

Ag-NOR profile was determined in the nuclei of 66 ovarian tumors and 6 normal ovarian tissues the results showed that assessment of Ag-NOR in tissue prints and paraffin sections can be of value in distinguishing benign from borderline and/or malignant ovarian tumors. This finding may be of clinical value particularly during operation. Borderline ovarian tumors with Ag-NOR profile similar to malignant lesions must be evaluated more seriously and prospective study must be done to establish precisely its malignant potential

Histopathological ocular changes of intraocular and intra-orbital retained aluminum foreign body [experimental comparative study]

An experimental histopathological comparative study on the effect of aluminium administered intra-orbitally and that administered intra occularly on the ocular tissues of rabbits was done. It has been found that aluminium particles administered intra orbitaly produced similar reactions to that occurred after administration of intra ocular ones. The mechanism by which intraorbital aluminium foreign body affected the intraocular structures was disussed