Head and neck cancer association to CIAP-2 expression due to human papillomavirus-16 [HPV-16] infection

It was relevant to assess the impact of a HPV-16 [human papillomavirus-16] which is a high-risk genotype on head and neck cancers and its relation to CIAP-2 expression [Cellular Inhibitor of apoptosis-2]. Tissue samples were taken from patients diagnosed as head and neck cancer. All samples were subjected to qualitative polymerase chain reaction [PCR] analysis for HPV, qualitative and semi-quantitative reverse transcription polymerase chain reaction [RT-PCR] of CIAP-2. There was a significant association between HPV-16 and CIAP2 positivity and head and neck tumors. CIAP-2 expression in malignant tissues was highly associated with HPV-16 infection at sensitivity 73.9% and absolute specificity

Adiponectin, leptin and oxidative stress in preeclampsia in Egypt woman

Adiponectin and Leptin are closely related adipokines that are associated with the oxidative stresses and endothelial dysfunction and proposed to participate in preeclampsia [PE] pathogenesis. This study is to determine changes in serum levels of adiponectin, leptin and oxidative stress in PB women in order to speculate a possible role of them in the pathogenesis and severity of PE. The serum levels of adiponectin and leptin are measured simultaneously by enzyme-linked immunosorbent assay. Malondialdehyde [MDA] was used as a marker for lipid peroxidation and measured by biochemical test. It is found that the levels of adiponectin are significantly lower in mild and severe PE and levels of leptin are significantly higher in mild and severe PB. The adiponectin/leptin ratios are, significantly lower in mild and severe PB than in control group as well as to its high significant difference between mild and severe PE. Whereas MDA levels are significantly higher in women with mild or severe PB than in control group and there are striking differences between the mild and severe PB in MDA levels. There is a significant negative correlation between serum levels of MDA and adiponectin and between adiponectin and leptin, and a significant positive correlation between serum levels of MDA and leptin in PB women [R=-0.424,-0.327,+0.309,] respectively. Therefore, PE is associated with hypoadiponectinemia and lipid peroxidation that may be a cause of increased leptin level. These may be utilized as sensitive and specific markers for PE diagnosis and severity