RESUMO
This work was undertaken to investigate the effect of 15 and 50 micro g/ml Triclabendazole-sulphoxide [TCBZ-SX] the active metabolite of the fasciolocide TCBZ on the activities of superoxide dismutase and catalase [SOD and CAT] as antioxidant enzymes and glutathione-S-transfers [GST] as detoxifying enzyme in the liver of normal and Fasciola gigantica infected cows and buffaloes. Of this study revealed that the drug when used in vitro had no effect on the activities of SOD and CAT in normal and fastciola gigantic a infected cows and buffaloes as well as on the activity of GST in normal and Fasciola gigantica infected buffaloes. This indicated that the changes noticed in the activates of the studied parameters were due to the effect of infection rather than the drug itself except for the GST in normal cows which showed a significant increase in the activity as a result of drug treatment. Differences in the levels of these enzymes between cows and buffaloes may be due to species variation. We could conclude that the drug didn't later the capacity of the three tested antioxidant and detoxifying enzymes