Qualite de la relation mere enfant dans la survenue des malnutritions proteino-energetiques. A propos de 102 cas colliges a l'hopital general de Port-Boue

Introduction-objectif : La Malnutrition Proteino- Energetique (MPE) est l'un des graves problemes de sante publique des enfants; d'origine multifactorielle Cette etude avait pour objectif de determiner la part des facteurs relationnels dans la survenue de la malnutrition proteino- energetique. Patients et methodes : cette etude prospective et descriptive a ete realise au service de pediatrie de l'Hopital General de Port-Bouet du 1 er fevrier 2003 au 30 septembre 2003 (08 mois) Resultats et discussion : les nourrissons etaient les plus representes (84;3) avec une predominance masculine (55;9) (inaugurale d'une carence affective) a l'origine du kwashiorkor (83;3) certaines caracteristiques sociodemographiques du nourrisson et du petit enfant telles que l'etat de sante a la naissance; le type d'alimentation ne sont pas specifiques aux MPE. Cependant; la condition d'enfant sevre (75;5) et l'association d'un tableau depressif (83;3) a l'expression clinique de cette MPE donnent ainsi raison aux societes africaines traditionnelles pour qui; le kwashiorkor est avant tout une depression d'abandon

Adolescence et pathologies psychiatriques: a propos de 100 cas colliges a l'hopital psychiatrique de Bingerville

L'hopital psychiatrique de Bingerville est le centre de reference des troubles psychiatriques en Cote d'Ivoire . Population et methode : Il s'agissait d'une etude retrospective des pathologies psychiatriques de dossiers de 100 adolescents hospitalises a l'hopital psychiatrique de Bingerville. Resultats : Ils indiquaient que; la majorite des patients (64) etait en fin d'adolescence (19-21ans). Les pathologies psychiatriques selon les criteres de l'OMS (CIM10) sont dominees par les troubles psychotiques aigus polymorphes sans symptomes schizophreniques (45); les troubles psychotiques chroniques (24) et les troubles bipolaires (20) ; tous declenches par des facteurs organiques (47); des facteurs psychologiques (37) et medicamenteux (16). Commentaires : Les facteurs qui ont declenche ou favorise ces decompensations etaient d'ordre organique; psychologique et medicamenteux (non observance d'un traitement psychotrope)

Classification of Some Wild Yam Species Tubers of Ivory Coast Forest Zone.

The tubers of some wild yam species (eight) found in the Ivory Coast forest were collected and their classification according to their nutrients and antinutritional factors was made by principal component analysis (PCA). The principal component analysis (PCA) of individuals, constituted by the yam species, according to nutrients considered as the variables, showed two principal axes of correlation F1 and F2. The percentages of variables dispersion around the principal axes F1 and F2 were equal to 72.86% and 20.24% respectively. The individuals projected on the principal axes F1 and F2 grouped into four classes around the axes. Around the axis F1 (72.26%): The class gathering the tubers of wild yam species D. minutiflora; D. will hirtiflora and D. bulbifera bulbil which contained more Moisture and the class gathering the tubers of wild yam species D. burkilliana; D. bulbifera tuber; D. dumetorum; D. praehensilis and D. mangenotiana which had the highest Energy Value. Around the axis F2 (20.24%): The class gathering the tubers of wild yam species D. burkilliana; D. bulbifera tuber; D. dumetorum and D. praehensilis which contained more Soluble carbohydrates and the class gathering the tubers of wild yam species D. minutiflora; D. hirtiflora; D. bulbifera bulbil and D. mangenotiana which contained more ash. The principal component analysis (PCA) of individuals, constituted by wild yam species, according to their Antinutritional factors considered as the variables, showed two principal axes of correlation F1 and F2. The percentages of variables dispersion around the principal axes F1 and F2 were equal to 35.88% and 31.99%) respectively. The individuals projected on the principal axes F1 and F2 grouped into 3 classes around axes: Around the axis F1 (35.88%): The class gathering the tubers of wild yam species D. mangenotiana; D. dumetorum; D. burkilliana; D. bulbifera bulbil; D. togoensis; D. bulbifera tuber and D. praehensilis which contained more, Tannins, Alkaloids and Hydrocyanic acid. Around the F2 axis (31.99%): The class gathering the tubers of wild yam species D. togoensis; D. dumetorum; D. minutiflora; D. mangenotiana; D. praehensilis and D. bulbifera bulbil which contained more Oxalic Acid and the class gathering the tubers of wild yam species D. togoensis; D. hirtiflora; D. minutiflora and D. dumetorum and which contained more Sapogenins.

Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis

Liver fibrosis progresses to cirrhosis in several settings, for example, severe acute alcoholic hepatitis, and hepatitis C virus [HCV] reinfection after liver transplantation. Cirrhosis produces hepatocellular dysfunction, which is also a risk factor for hepatocellular carcinoma. We studied verapamil as a prophylactic, therapeutic antifibrotic drug alone and in combination with silymarin in experimental rat's liver-induced fibrosis. Liver fibrosis was induced by intra-peritoneal injection of rats with pig serum 0.5 ml twice weekly for 6 weeks, which resulted in score three fibrosis. Prophylactic verapamil alone and silymarin alone and a combination of both were administered at the same time of induction of liver fibrosis and continued for the duration of induction. Therapeutic verapamil was started on the last day of fibrosis induction and continued for 4 weeks. The extent of liver fibrosis was evaluated using Ishak's fibrosis score. Serum alanine aminotransferase [ALT] was measured for follow-up. Compared to fibrotic model rats, prophylactic verapamil, silymarin and combined verapamil plus silymarin significantly resulted in lower serum ALT levels. Prophylactic use of verapamil and silymarin each alone revealed score 2 fibrosis with positive alpha-SMA immunostaining; while prophylactic treatment with combined verapamil plus silymarin revealed no fibrosis supported by negative alpha-SMA immunostaining. Verapamil treated fibrotic rat's liver revealed significant regression in liver fibrosis scores with positive alpha-SMA immunostaining. Verapamil alone has a more significant prophylactic than therapeutic antifibrotic effect against induced liver fibrosis; it was more significant than silymarin. The combination of verapamil and silymarin, showed the best protection through their synergistic antifibrotic effect

Modulatory effect of L - arginine [nitric oxide precursor] on aspirin - induced changes in gastric mucosa and motility in rats.

In this study, L-arginine was administrated orally [p.o.] at a dosage of 10, 20 and 40 mg/kg of body weight, acutely once and chronically daily throughout two weeks prior to ulcer induction. Gastric mucosal lesion was induced by single oral administration of aspirin 300 mg/kg body weight suspected in water, after 36 hours fasting. The rats were killed within 24-48 hours and the gastrointestinal tract was subjected to gastric motility study and examined for the evidence of gross or microscopic change. The obtained results indicated the relaxant effect of L-arginine on gastric fundus and its protective role against the aspirin-induced ulcers in the rat