significance of C-reactive protein in adult obese and centrally obese group

To see the significance of C-reactive protein in adult obese and centrally obese groups. Descriptive Study. This study was carried out from free camp for obesity in Clifton area and Punjab Colony, Karachi from November 2010 to April 2011. Overweight adults [20-40 years] were selected along with the history of Xanthomas, yellow coloration of eyes, and high blood pressure and cardiac arrest.100 samples were taken for lipid profile, and C-reactive protein [CRP]. The Body Mass Index [BMI] and waist hip ratio was measured by following the criteria of the National Heart Lung And Blood Institute. Hundred patients were selected for the purposes of study. These patients were divided into two categories i.e. adult obese and centrally obese. Body mass index [BMI] was increases [M=31.27 +/- 1.2, F= 31.3 +/- 0.27] in both sexes of adult, whereas waist hip ratio was slightly increases in adult male [1.22 +/- 0.04] as compared to female[1.14 +/- 0.025]. In comparison of centrally obese male and female, body mass index was high in females [34.1 +/- 0.67] as compared to male [31.68 +/- 0.53], but waist hip ratio was elevated in male cases [2.16 +/- 0.14] than female [2.16 +/- 0.14], when compared with control cases. Whereas C-reactive protein was high in female cases [27.8 +/- 1.20] as compared to male [24.20 +/- 0.86]. In case of centrally obese, markedly increased level was observed in female [30.63 +/- 2.57] as compared with male [28.9 +/- 2.35]. There is significant effect of inflammatory marker C-reactive protein in both male and female obese and centrally obese adult groups

Insulin deficiency among newly diagnosed type 2 diabetics

Any patient above the age of 40 years, coming with the symptoms of diabetes is labelled as type 2 diabetic. If insulin levels are included in the protocol for initial investigations of diabetic patients, they can be differentiated as having insulin deficiency or insulin resistance. They can thus be treated accordingly. This study was conducted to see the prevalence of insulin resistance and insulin deficiency in newly diagnosed type 2 diabetics. This study was conducted on 75 newly diagnosed diabetic subjects, and 75 control subjects for comparison. Fasting serum insulin was assayed by ELISA and HOMA-IR index was calculated. The diabetic subjects with fasting hyperglycaemia and serum insulin level below 20 micro IU/ml and HOMA-IR index below 3.5 were grouped as insulin deficient [Group-A], and the diabetic subjects with fasting insulin level above 20 micro IU/ml and HOMA-IR index above 3.5 were grouped as insulin resistant [Group-B]. Twenty-eight percent subjects were found to have insulin level below 20 micro IU/ml while 72% subjects had insulin resistance. When gender was taken into consideration, it was seen that 18.7% males had fasting insulin level of 6.98 +/- 0.737 micro IU/ml and 9.3% females had fasting insulin level of 5.21 +/- 0.885 micro IU/ml while 32% males and 40% females had insulin resistance. The mean age of male subjects with insulin resistance was significantly higher compared to the male subjects with insulin deficiency. Mean weight and body mass index of the male and female subjects having insulin resistance was significantly higher than their respective control groups and also higher than the subjects with insulin deficiency. Pearson coefficient of correlation was calculated for fasting serum insulin level with age and BMI. A significant positive correlation was observed between fasting serum insulin and age of females with insulin resistance. A considerable number of persons who develop diabetes after 40 years of age but are not insulin resistant. Twenty-eight percent subjects have relative insulin deficiency, and 72% subjects have insulin resistance.