Elevation of serum triglyceride concentration in association with hepatic microsomal enzyme induction after treatment with phenylbutazone and diclofenac sodium in rats

The relationship between serum triglyceride concentration and hepatic microsomal enzyme activity was examined in rats. Two groups of rats were injected with diclofenac sodium at doses of 2.5 and 5 mg/kg/day. A third group was injected with phenylbutazone at a dose of 20 mg/kg/day. The results indicated that the possibility of hypertriglyceridemia as an adverse effect of the induction of the hepatic microsomal enzymes, following the administration of phenylbutazone and diclofenac sodium, should be considered