Teratogenic and histopathological effects of citrullus cologynthis plant extract

The teratogenic and histopathological exploration of the minced extract ofCitrullus colocynthis fruits were studied on forty pregnant albino ratsdivided into four equal groups. The first three groups were given 1/4 LD 50of the active ingredient of the minced extract while the fourth group was keptas control. The results showed that the minced fruits extract of the planthas a toxicological effect on pregnant rats reproduction and induced skeletalabnormalities of their foeti. The microscopical picture of lung, liver andkidney of pregnant rats in the first three groups showed a varioushistopathological alterations