Evaluation of sHLA-G levels in serum of patients with prostate cancer identify as a potential of tumor marker / 대한해부학회지

Prostate cancer is the most common cancer type in men and is the second cause of death, due to cancer, in patients over 50, after lung cancer. Prostate specific antigen (PSA) is a widely used tumor marker for prostate cancer. Recently, PSA is discovered in non-prostatic cancer tissues in men and women raising doubts about its specificity for prostatic tissues. PSA exists in low serum level in healthy men and in higher levels in many prostate disorders, including prostatitis and prostate cancer. Thus, a supplementary tumor marker is needed to accurately diagnose the cancer and to observe the patient after treatment. Recently, soluble human leukocyte antigen-G (sHLA-G) has been introduced as a new tumor marker for different cancer types, including colorectal, breast, lung, and ovary. The present descriptive-experimental study was carried out including patients with malignant prostate tumor, patients with benign prostate tumor, and a group of health men as the control group, as judged by an oncologist as well as a pathologist. After sterile blood sampling, sHLA-G was measured by enzyme-linked immunosorbent assay in each group. The data was then analyzed using one-way ANOVA. P≤0.05 was considered as statistically significant. The results showed that the mean of sHLA-G level was high in patients. Also, it was found that there was a significant difference in sHLA serum level between the three groups. The data revealed that sHLA-G can be a novel supplementary tumor marker in addition to PSA to diagnose prostate cancer.

Erratum to: Evaluation of sHLA-G levels in serum of patients with prostate cancer identify as a potential of tumor marker / 대한해부학회지

No abstract available.

[Evaluation of diagnostic value of DW sequence in differentiating infectious spondylitis from degenerative endplate type1]

Background and Objectives: DWI is one of the useable sequences in MRI which currently being used in the assessment of vertebral column especially for malignant or benign causes. Considering that few studies have been performed regarding the use of DW sequences in spondylitis differentiating of disease with degenerative changes of vertebral yet; hence we intended to found the diagnostic value of DW sequence in spondylitis differentiating of infectious from degenerative changes of end plate type 1 with designing this study

Materials and Methods: This study was carried out on patients who referred to the Pejvak MRI center with spondylitis lesions and osteochondrosis grade I, involving the vertebral column during 2012-2013; and to differentiate these lesions was used the T1, T2 and DWI sequences. Obtained results were analyzed by SPSSv16 statistical software

Results: In this study, in T1WI sequences the images of both groups was hyposignal and in T2WI sequences was hypersignal [p=0.01]. In DW sequence with b value of 50, 400 and 800 [s/mm[2]] was observed that the signal changes in higher b value was apparent and in lower b value both detection had many similarities to each other due to the annoying effect of T2 Shine-through. As well as the mean of ADC map in spondylitisis images] 1.31 +/- 0.24x 10-3 mm2 /s[was less than osteochondrosis grade I with a mean ADC map [1.79 +/- 0.24x 10-[3] mm[2] /s] P<0.001]

Conclusion: The results of this study showed images with high b value could be having a good differentiation to distinguish the spondylitis from osteocondrosis