study of the potential role of aldose reductase inhibitors [Sorbinil, Tolrestat and Ponalrestat] in the amelioration of nephropathy in diabetic rats

This work included 90 male albino rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin [STZ] in a dose of 55 mg/kg body weight. One week after STZ injection, uninephrectomy was done and the study began one week after uninephrectomy operation and continued for eight months. The results revealed that oral administration of sorbinil, tolrestat or ponalrestat for eight months in uninephrectomized [UNE] diabetic rats produced significant decreases in sorbitol and fructose levels in RBCs, kidney sorbitol and aldose reductase activity in RBCs associated with significant increases in Na