RESUMO
Objective: To determine the effectiveness of vitamin C supplementation in preventing pre-labour rupture of chorio-amniotic membranes [PROM] in pregnancy in women having history of PROM in previous pregnancies
Methodology: this descriptive study was carried out in Department of Obstetrics and Gynaecology, Khyber Teaching Hospital, Peshawar from August 2013 to January 2014. Cases with history of PROM in previous pregnancies were included in this study. Vitamin C supplementation in preventing PROM was used in these patients. All pregnant patients presented from 22 to 28 weeks gestation received a daily dose of Vitamin C 500mg. PROM at the end of pregnancy was noted
Results: out of 133 patients who received Vitamin C, 98 [74%] didn't experienced PROM and 35 [26%] had PROM, showing the effectiveness of Vitamin C in preventing PROM which is effective in 74%
Conclusion: in our study Vitamin C was proved to be helpful in preventing PROM and it is suggested that patients with previous history of PROM should be given vitamin C supplementation
RESUMO
To describe the frequency and clinicopathological presentation of malignancies of the female genital tract presenting to a tertiary care hospital. This descriptive study was carried out at Department of Obstetrics and Gynaecology, Unit A of Khyber Teaching Hospital, Peshawar from January 2008 to December 2012. A total of 4657 patients were admitted during the study period and all the patients having genital tract malignancies were included. Detailed history was taken and relevant examinations and investigations were carried out. Surgical procedures were performed where needed and specimens were sent for histopathology. Clinical and surgical staging was also carried out. All the details were noted down on a semi-structured proforma. There were 43 cases of gynaecological malignancies with mean age of 43.74 +/- 15.51 years. Ovarian cancer was the most common [n=22, 51.22%] followed by uterine cancer [n=10, 23.33%]. The majority of patients diagnosed with ovarian cancers [n=9/22, 40.94%] were nulliparous, whereas the majority of uterine and cervical cancers were multiparous [n=7/10, 70.0%] and grand multiparous [n=7/9, 77.78%], respectively. Ovarian cancers mostly presented with an abdominal mass [n=16/22, 72.7%] while uterine and cervical cancer presented with irregular cycles [n=7/10, 70.0%] and post coital bleeding [n=4/10, 40%]. Advanced stage cancer cases were 19/43 [44.22%]. Serouscystadeno carcinoma was the most common ovarian malignancy [n=16/22, 72.73%] while endometrioid adenocarcinoma [n=9/10, 90%] was the most common uterine carcinoma and squamous cell carcinoma was the most common cervical carcinoma [n=7/9, 77.88%].Conclusions: Ovarian cancer was the most commonly encountered malignancyal though all gynaecological malignancies are rare