Elucidation of Immunomodulating Potential of Morus alba against Sub Acute Exposure of Fipronil in Rats

Immunotoxicity is defined as adverse effects on the functioning of the immune system that results from exposure to chemical substances. The present investigation was carried out to evaluate immunomodulating effect of Morus alba (500mg/kg B.w.) against immunotoxicity induced by sub-acute exposure of Fipronil (10mg/kg B.w.) in rats. Sub-acute immunotoxicity was conducted in adult male wistar rats. Rats were randomly divided into four groups (6 rats/group). Group I served as control in which corn oil (acting as a vehicle of Fipronil) was administered @10 ml/kg B.w. Group II served as Fipronil treated group @10 mg/kg B.w. In Group III Fipronil along with Morus alba fruits extract @ 300 mg/kg B.w. was administered and in Group IV Morus alba fruits extract @ 300 mg/kg B.w. was administered. Vehicle, Fipronil and Morus alba were administered daily to the rats by oral gavage for 28 days. The dose of fipronil was selected on the basis of LD50 in rats. TLC, DLC, serum total protein, albumin, globulin, A:G ratio, serum antibody titer/haemagglutination (HA) titer and delayed type hypersensitivity (DTH) response were estimated. Fipronil produced immunotoxicity in the form of alteration from normal values in these parameters. Morus alba was significantly effective in restoration of these parameters towards normal. The study suggested that Morus alba has immunomodulating potential against toxicity induced by fipronil in rats.

Ameliorating Potential of Panax Ginseng on Oxidative Stress following Subacute Exposure to Acetamiprid in Rats

Oxidative stress is common when the cellular antioxidant capacity is overwhelmed by the reactive oxygen species generated by the metabolism of pesticides which either inhibit or modulate the expression of antioxidant enzymes. The present study was made with objective to evaluate the ameliorating potential of Panax ginseng on oxidative stress following subacute exposure to Acetamiprid in rats. Twenty four adult male Wistar rats were divided in four groups comprising six each. Group I served as control and was administered with groundnut oil (1ml/100gm), group II was administered with Acetamiprid (52.5 mg/kg body weight), group III served as Panax ginseng (50 mg/kg body weight) control and in group IV possible ameliorative effect of Panax ginseng was examined against Acetamiprid. Vehicle, Acetamiprid and Panax ginseng were administered daily to the rats orally by gavage for 28 days and animals were sacrificed at the end. Liver, kidney, spleen and brain were processed for determination of oxidative stress related parameters viz: Lipid peroxidation (LPO), reduced glutathione (GSH), Superoxide dismutase (SOD), catalase and glutathione reductase (GR) levels. Acetamiprid produced toxicity which was evident in the form of enhanced lipid peroxidation and decrease in activities of GSH, SOD, catalase and glutathione reductase levels in all the organs examined. Panax ginseng was significantly effective in restoration of these parameters towards normal. Thus, it was concluded that Panax ginseng has ameliorating potential on oxidative stress following subacute exposure to acetamiprid in rats

Klippel-Trenaunay Syndrome - A Case Report.

Klippel-Trenaunay Syndrome (KTS) is a sporadic disorder characterized by the triad of vascular malformation (capillary hemangioma or port wine stain), venous varicosity and soft tissue and/ or bony hypertrophy. We report here a case of Klippel-Trenaunay syndrome with review of literature.

Perinatal outcome in growth retarted babies born to normotensive and hypertensive mothers: A prospective study.

Pregnancy induced hypertension is one of the common condition of unknown etiology which increases the maternal and perinatal morbidity and mortality. The present study was carried out to find the perinatal outcome in intra-uterine growth retarted (IUGR) babies born to 110 mothers with pregnancy induced hypertension (PIH) and 100 normotensive mothers. The incidence of small for gestational age (SGA) was four times more in the hypertensive group; outcome in terms of morbidity and mortality was also statistically significant. The study further revealed that 57.1% babies were preterm and intra-uterine growth retarded (IUGR) in the study group, 71% of them being asymmetrical. The study was aimed to know the problems likely to be encountered in early neonatal period.

Mature mediastinal teratoma- A rare cause of recurrent respiratory distress.

Teratomas are interesting because of their obscure origin,bizarre microscopic appearance and sometimes unpredictable behaviour.Although they occur infrequently in children, clinician should be aware of their clinical features, natural history, pathology and principles of treatment.In an attempt to document some of the features ,we report a case of an infant with large mediastinal teratoma presenting with severe and recurrent respiratory distress. Patient was operated successfully with no recurrence in 1 year follow up.