A Study comparing latanoprost and unoprostone in open angle glaucoma and ocular hypertension

A 1-month randomized study comparing the intraocular pressure (IOP) reducing effect of latanoprost 0.005% administered in the evening with unoprostone 0.12% given twice a day in primary open angle glaucoma and ocular hypertension was performed.A total of 27 patients were included:12 were in the latanoprost group and 15 in the unonoprostone group.Mean IOP was reduced from 27.38 mm HG with latanoprost and from 26.59 to 22.16 mm Hg with unoprostone as determined at the end of the 1-month period.No upward drift in IOP was seen with either drug during the treatment period.Thus,latanoprost 0.005% administered once daily in the evening, reduced IOP more than the unoprostone given twice daily in primary open angle glaucoma and ocular hypertension.