The effects of organophosphate insecticides on the activities of some erythrocyte antioxidant enzymes, total antioxidant status and lipid peroxidation in the blood of workers in insecticide factory

The workers in insecticide factory generally are exposed to organophosphate insecticide chemicals while working in the plants. We have investigated the effects of organophosphate insecticides on the activities of some erythrocyte antioxidant enzymes, total antioxidant status and lipid peroxidation in the blood of the insecticide producing workers. The results: (1) erythrocyte superoxide dismutase (SOD) and glutathione reductase (GR) activities were significantly depressed by 37.64% and 28.55%, respectively while serum cholinesterase (ChE) activity was only depressed by 13.47% as compared with an unexposed group; (2) erythrocyte glutathione peroxidase (GPx) was increased significantly; (3) serum total antioxidant status (TAS) was depressed by 9.86% (p>0.05). This preliminary study suggests that erythrocyte SOD may be a sensitive indicator of exposure to organophosphate insecticides.

The in vitro effects of methamidophos on oxygen uptake, carbonic production

(MAP) on O2 uptake, CO2 production and rate of methemoglobin of human erythrocytes. The in vitro effects of methamidophos (MAP) on O2 uptake, CO2 production and rate of methemoglolin of human erythrocytes were studied: (1) after exposure of human erythrocytes to MAP at the concentrations from 1 to 10mM, only at concentration higher than 100mM of MAP in 37oC for 3 hours, the hemolysis was significantly induced. (2) at MAP concentrations between 1 and 10 mM, the significant increase of oxygen uptake and carbonic productions in human erythrocytes was seen. (3) At MAP concentrations between 1 and 10 mM, rate of methemoglobin in erythrocytes was increased significantly. These findings suggest that MAP act as oxidative chemical

Influence of in vitro methamidophos on the activity of some antioxidant enzymes and peroxidation in the human erythrocyte

In vitro study on effects of methamidophos (MAP) on antioxidant enzymes, total antioxidant status (TAS) and lipid peroxidation of human erythrocytes have shown: human plasma total antioxidant status (TAS) and enzym cholinesterase (ChE) activity were significantly decreased by increasing MAP concentrations (from 5 to 10 mM) and incubation period. Human erythrocyte superoxi.