Analysis on clinical effect of clopidogrel hydrogen sulfate plus nimodipine in treating transient cerebral ischemic attack / 重庆医学

Objective To investigate the efficacy and safety of clopidogrel hydrogen sulfate plus nimodipine in treating transient cerebral ischemic attack.Methods A total of 159 outpatients and inpatients with transient cerebral ischemic attack in the neurosurgery department and the neurology outpatient department of our hospital from January 1,2012 to September 1,2016 were divided into 3 groups.The group A(43 cases) orally took clopidogrel hydrogen sulfate plus aspirin;the group B (51 cases) treated with oral clopidogrel hydrogen sulfate plus nimodipine;the group C(65 cases) was treated with clopidogrel hydrogen sulfate plus nimotop.The curative effects were observed in 3 groups.The differences of PT.APTT,FIB and PLT in 3 groups were compared between before and after treatment.Results The total effective rate of the group A and C was significantly better than that of the group B(P0.05);the effect of the group B and group C on coagulation was superior to that of the group A(P<0.05).The three group had no severe bleeding events(cerebral bleeding,etc.),the difference was statistically significant.Conclusion Clopidogrel hydrogen sulfate combined with nimotop can significantly reduce the frequency of transient cerebral ischemic attack,has little influence on the coagulation indicators,and is safe and effective.

Applicational research progress of Glasgow Coma Scale, Children Coma Scale and Trauma Infant Neurologic Score in children with traumatic craniocerebral injury / 中华实用儿科临床杂志

Traumatic craniocerebral injury is one of serious injury which can cause great damage to human life and health even lead to disability or death.Making an objective and accurate judgement of severity and prognosis for traumatic craniocerebral injury in children,which might play an important role in the clinical treatment and prognosis.As a physical scoring indicator system of traumatic craniocerebral injury,the earliest and most widely used one is Glasgow Coma Scale.The Children Coma Scale is particularly used for children under 4 years old and the Trauma Infant Neurologic Score for infants with traumatic craniocerebral injury.Thus,these 3 scoring systems present advantage and representative in clinical application.Here we make a brief review on these 3 scoring systems based on the current studies and applications.