Clinical progress in pediatric melanoma / 中华皮肤科杂志

Pediatric melanoma occurs rarely, and the pathogenesis is different in different subtypes. The diagnostic criteria for adult melanoma may not be fully applicable to pediatric patients due to atypical clinical manifestations of some tumors. Surgery is the first-line treatment, and the accurate resection margin could be smaller than that in adults. In recent years, immunotherapy and targeted therapy for melanoma have developed rapidly, but very few drugs have been approved for children. Although there have been few large-sample studies on the treatment of pediatric melanoma, the application of related drugs has been reported in literature. This review summarizes progress in the pathogenesis, clinical manifestations and treatment of pediatric melanoma, in order to provide a reference for the diagnosis and treatment of pediatric melanoma.

Research progress on lncRNAs as members of ceRNA network in melanoma / 国际肿瘤学杂志

In recent years, there has been an increasing number of studies on long non-coding RNAs (lncRNAs) as a competing endogenous RNA (ceRNA) in melanoma. Different lncRNAs show high or low expression in melanoma, and competitively combine with miRNAs through ceRNA mechanism, affecting the expression of downstream target mRNAs, thereby playing the role of oncogenes or tumor suppressor genes. Understanding the role of lncRNA as ceRNA in melanoma can provide new ideas for the diagnosis and treatment of melanoma in the future.