RESUMO
Interaction of frusemide and digitalis on frog heart has been studied. It was found that like digitalis, frusemide did not have any effect on normal heart, but restored the normal myocardial contraction of the hypodynamic frog heart. Frusemide induced cardiac arrest when administered during digoxin infusion. It is suggested that interaction of frusemide and digoxin has additive effect.
Assuntos
Animais , Digoxina/farmacologia , Interações Medicamentosas , Furosemida/farmacologia , Coração/efeitos dos fármacos , Parada Cardíaca/induzido quimicamente , RanidaeRESUMO
Intravenous injection of synthetic oxytocin (Syntocinon) causes a fall of blood pressure in rabbit. The hypotensive response was potentiated after vagotomy and atropine. Beta-adrenergic and 5-HT blockers reduced the hypotensive response to oxytocin. Hypotensive response of oxytocin in rabbit involves two factors, activation of beta-adrenergic receptor and release of 5-HT.
Assuntos
Antagonistas Adrenérgicos beta/farmacologia , Animais , Atropina/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Feminino , Masculino , Ocitocina/antagonistas & inibidores , Coelhos , Antagonistas da Serotonina/farmacologiaRESUMO
Intravenously administered oxytocin caused a dose-related fall in blood pressure of the rabbit. When oxytocin was administered in oestrogen-primed animals, the depressor response was converted to a pressor one "Oxytocin reversal". The "oxytocin reversal." was abolished after treatment with dihydroergotamine, hexamethonium or adrenalectomy. The "oxytocin reversal" did not appear in reserpinized animals.