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J Health Popul Nutr ; 2008 Dec; 26(4): 388-96
Artigo em Inglês | IMSEAR | ID: sea-713

RESUMO

The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$ 7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.


Assuntos
Brasil , Pré-Escolar , Estudos de Coortes , Análise Custo-Benefício/estatística & dados numéricos , Feminino , Gastroenterite/economia , Humanos , Lactente , Masculino , Rotavirus/efeitos dos fármacos , Infecções por Rotavirus/economia , Vacinas contra Rotavirus/economia
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