Performance of circulating placental growth factor as a screening marker for diagnosis of Ovarian Endometriosis: a pilot study

Background: The aim of this study is to compare the circulating placental growth factor [PlGF] concentration in women with and without endometrioma to verify the performance of this marker to diagnose the disease

Materials and Methods: In this case-control study, thirteen women with histological diagnosis of ovarian endometriosis were compared with women without endometriosis disease. PlGF plasma levels of endometriotic patients and controls were investigated using a fluorescence immunoassay technique

Results: PlGF showed a direct correlation with body mass index [BMI] only in the control group [P=0.013]. After adjustment for BMI values, PlGF median value in endometriosis group [14.7 pg/mL] resulted higher than in control group [13.8 pg/ mL, P=0.004]

Conclusion: PlGF is a promising peripheral blood marker that can discriminate between patients with and without ovarian endometriosis

Sarcoma de Kaposi perianal. Presentación de un caso y revisión de la literatura / [Perianal Kaposi’s sarcoma. A case report and a review of the literature].

Kaposi’s sarcoma is the most common cancer in men who have sex with men with AIDS. The estimated prevalence in the United States is 25

in patients with positive serology for the human immunodeficiency virus (HIV). The commitment of the gastrointestinal tract is seen in 40

of patients with Kaposi’s sarcoma related to AIDS but lesions can occur anywhere in the body and evolve rapidly. We present a 33-year-old patient who kept sex with men, with epidemiological history of hepatitis B and syphilis, who consulted the service of Coloproctology for perianal ulcer. He was studied according to the protocols of sexually transmitted diseases, was diagnosed HIV and an excision biopsy of the lesion was performed. The diagnosis of perianal Kaposi’s sarcoma was reached. Kaposi’s sarcoma-HIV was staged, no other lesions were found and the patient started antiretrovirals with poor response to therapy. He evolved with rapid progression of the disease and died with the presumptive diagnosis of Fournier’s syndrome at three months after the excision biopsy. We conclude that perianal ulcers are a relatively common pathology in the office of Coloproctology and differential diagnosis are different according to the positivity for HIV or not and the patient’s sexual practices. We consider that is important to publish and spread these cases.