RESUMO
A glucosidase inhibition assay has been used to evaluate extracts from higher plants. An enzyme inhibition of fifty percent or more correlated with the observed cytotoxicity of the extracts
Assuntos
beta-Glucosidase/antagonistas & inibidores , Extratos Vegetais/farmacologia , Avaliação Pré-Clínica de Medicamentos/métodos , Antivirais/farmacologia , Morte Celular/efeitos dos fármacos , HIV/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Extratos Vegetais/toxicidade , Porto RicoRESUMO
Extracts from higher plants were evaluated for inhibitory activity against avian myeloblastosis virus reverse transcriptase. The assay may serve as a useful prescreen for potential anti-HIV bioactives
Assuntos
Antivirais/farmacologia , Extratos Vegetais/farmacologia , DNA Polimerase Dirigida por RNA/antagonistas & inibidores , Avaliação Pré-Clínica de Medicamentos/métodos , HIV/efeitos dos fármacos , Porto Rico , Vírus da Mieloblastose Aviária/enzimologiaRESUMO
Four bacteria-derived immunopotentiators were tested for their protective effect on a P-388 mouse lymphocytic leukemia model. The microbial test products were prepared from the following bacterial strains: ATCC 35983 Staphylococcus epidermidis isolated from a patient with IV catheter; ATCC 31874, a patented strain listed as Staphylococcus epidermidis isolated from the urine of a cancer patient; ATCC 25615 Staphylococcus hominis obtained from a child with lymphocytic leukemia, and ATCC 25614 Staphylococcus warneri, an isolate from a patient with adenocarcinoma of the breast. A limited degree of protection and prolongation in survival time was observed in the animal group treated with the bacterial strain ATCC 31874