RESUMO
<p><b>OBJECTIVE</b>Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively.</p><p><b>METHODS</b>Extracts of M. paniculata made with petroleum ether (60-80 °C), chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions (F-F). Fraction F(100 mg/kg), which showed notable anxiolytic activity, was further chromatographed to get four subfractions (F-F). Simultaneously, the ethanol extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction (EASF) and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M. paniculata leaf extract by thin-layer chromatography was also carried out.</p><p><b>RESULTS</b>Fraction F(25 mg/kg) and EASF (20 mg/kg) showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity.</p><p><b>CONCLUSION</b>The results validate the traditional use of M. paniculata leaves in the treatment of mental disorders.</p>
RESUMO
Background: Abnormal uterine bleeding is the commonest presenting symptom and major gynecological problem responsible for as many as one-third of all out patient gynecologic visit. An understanding of the varieties in the normal morphological appearance of the endometrium provides an essential background for the evaluation of endometrial pathology. Aims: To study the histopathology of endometrial biopsies in patients presenting with abnormal uterine bleeding and its correlation with age, parity and bleeding pattern Methods: This was a study done at tertiary care hospital from 2012-2014. Endometrial biopsies obtained from 100 cases of patients presenting with abnormal uterine bleeding were studied followed by correlation of endometrial histopathology with parity, age and bleeding pattern. Results: The most common age group presenting with abnormal uterine bleeding was 41-50 years (31%).The commonest pathology was proliferative endometrium (29%).The commonest bleeding pattern was menorrhagia (88%) and highest incidence was seen in multiparous women(58%).Conclusion: Endometrial biopsy should be recommended during the workup of patients presenting with abnormal uterine bleeding to exclude organic pathology of endometrium.