Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches.

The main objective of the present study was to develop matrix-moderated transdermal systems of Indomethacin using various proportions of Ficus carica fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro permeation studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Indomethacin with Ficus carica fruit mucilage by the solvent evaporation technique. The interactions between Indomethacin and Ficus carica fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as permeability enhancer. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus carica increased. It was concluded that Indomethacin can be developed as a transdermal patches with Ficus carica fruit mucilage.

Dual acting oral floating matrix tablets of ranitidine hydrochloride.

The main purpose of this work was to prepare floating matrix drug delivery system of Ranitidine. Floating matrix tablets of Ranitidine were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. Floating matrix tablets containing 100 mg Ranitidine were developed using different effervescent salts and polymer combinations. The tablets were prepared by direct compression technique, using polymers such as hydroxyl propyl methyl cellulose (HPMC K4M), Carbopol 934 in combination. Sodium bicarbonate, citric acid, calcium carbonate was incorporated as a gas-generating agent. The effects of sodium bicarbonate on drug release profile and floating properties were investigated. The formulation was optimized on the basis of acceptable tablet properties, floating lag time, total duration of floating and in vitro drug release. The formulated tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies, floating lag time indicated that formulations F4 exhibited good and controlled drug release. Applying the linear regression analysis and model fitting showed the selected formulation F4 showed diffusion coupled with erosion drug release mechanism, followed first order kinetics. Optimized floating matrix tablets F4 showed no change in physical appearance, drug content, or in dissolution pattern after storage at 250C/ relative humidity 65% and 40°C / relative humidity 75% for a period of 3 months.

Novel approach in formulation and evaluation of mouth dissolving tablets of ondansetron hydrochloride.

Mouth dissolving drug delivery systems has number of advantage viz., faster onset of action, elegance, ease of administration, ease of manufacturing, ease of storage and transport. A novel attempt has been made to develop mouth dissolving tablets of Ondansetron hydrochloride by including clove oil as flavor and local anesthetic on taste buds. The tablets were prepared by direct compression technique. The formulated tablets were evaluated for Pre formulation and post formulation parameters and they were found to be saatisfactory. Direct compression method was employed for making mouth dissolving tablets. The formulated mouth dissolving tablets possessed good drug releasing property, good mouth feel and improved drug availability with better patient compliance.