RESUMO
The effects of a single dose of KIN-804 and MISO on liver and Ehrlich solid carcinoma [ESC] have been studied in Swiss albino mice. KIN-804 and MISO were administered at doses of 800 and 400 mg/Kg body weight, respectively. Liver glucose-6-phosphatase [G-6-pase], glutathione content and superoxide dismutase of ESC, were measured at different times from drug administration. [G-6-pase] was elevated significantly 24 hours after MISO only, while GSH and SOD showed nearly the same changes after MISO and KIN 804. Therefore, KIN-804 is a less toxic radiosensitizer and should be implicated in clinical trials
Assuntos
Animais de Laboratório , Misonidazol/farmacologia , Camundongos , Neoplasias Hepáticas/tratamento farmacológico , Carcinoma de Ehrlich/tratamento farmacológico , RadiossensibilizantesRESUMO
Twelve subjects with radiosensitive malignancies in the head and neck and 12 control normal patients with healthy gingival tissues are included in this study. A single specimen was taken from the gingiva of control patients, while 3 specimens where taken from the radiotherapy patients [before, after, and 6 months later radiotherapy]. Lypholisation of the tissues was done and Apizym kit was used. The results showed significant biochemical changes in the enzymatic activities of the gingival tissues after radiotherapy. A difference is quite apparent between control and radiotherapy group, for all enzymes except for estraselipase and B-galactosidase. These changes are expected to participate significantly in the histopathochemical and clinical changes in the role tissue after radiotherapy