Unusual anatomic location of a primary intracranial yolk sac tumor

A nongerminomatous germ cell tumor occurring in the brain parenchyma is extremely rare. A 2-year-old boy presented with symptoms of abnormal movements in the hand and mouth. MRI scanning revealed a lesion occupying the left temporoparietal region. Craniotomy was performed and the tumor was removed by en bloc resection. Histological examination revealed that the tumor was arranged in a reticular pattern, and Schiller-Duval bodies were evident at the center of the tumor. Immunohistochemical study showed that the tumor cells were positive for alpha-fetoprotein and vimentin, but negative for glial fibril-lary acidic protein. The histological diagnosis was pure yolk sac tumor

Unusual association between adrenal leiomyoma and autoimmune disease

Adrenal leiomyoma is a rare solid tumor of unknown etiology. Here, we present a case of a 38-year-old woman, a known case of Hashimoto's thyroiditis, presented with right adrenal mass incidentally discovered by computed tomography imaging. The mass was non-functioning according to laboratory results, but because the mass increased in size in a follow up visit, she underwent right adrenalectomy. The histological findings confirmed the diagnosis of adrenal leiomyoma, which was supported by a panel of immunohistochemical stains. Surprisingly, there was a dense lymphocytic infiltrate in the background of the tumor, forming germinal centers. Although most of the reported adrenal leiomyoma cases are associated with immune deficiency, none of the previous cases was associated with an autoimmune disease. We report a case of an unusual adrenal leiomyoma with a dense lymphocytic infiltrate

Role of troponin T and I in acute myocardial infarction

The study was consisted of one hundred patients admitted to the CCU with chest pain diagnosed as AMI and non-AMI diagnosed according to the WHO criteria. Fifty patients [30 males and 20 females, age 42 to 65 years] with AMI and 50 patients [36 males and 14 females, age 45 to 65 years] with non-AMI. Serum aliquots were taken from routine cardiac enzyme [total CK, CK-MB activity] and samples were collected from patients in the CCU. The blood samples were collected in evacuated gel tubes for serum preparation and allowed clotting at room temperature before centrifugation. Serum aliquots were stored at '70°C for later batch analysis of other cardiac markers [TnT, TnI] then thawed once just before analysis. Troponin-I was measured on AxSYM, Aboote Laboratories, Abbott Park, IL, USA. Troponin-T was measured on Elecsys 1010, Boehringer Mannheim, Mannheim, Germany. The median and range values of the cardiac markers was 3.3 [0.01-25] ng/ml in AMI and 0.1 [0.01-1-4] ng/ml in non-AMI patients for Troponin-T. The corresponding values for Troponin-I in AMI patients was 50 [0.4-50] ng/ml and 1.0 [0- 5] ng/ml in non-AMI patients. The sensitivity and specificity at the specified cutoffs for all patients are shown in Table I. There were 17 false negative results for troponin-T and 23 false negative for troponin-I at admission. However, at 12-24 hours after admission, there was only one false negative for troponin-T and three false negatives for troponin-I. There was also one false positive for troponin-I in patients with pulmonary edema, and two false positive for troponin-T in patients with end-stage renal failure and cardiomyopathy. The two false positive troponin-T results that were coming from 2 patients, diagnosed as cardiomyopathy, complicated with renal failure