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Objective To probe into modulation effect between the EDRF/NO And AngⅡ.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic changes of plasm AngⅡ-ir,cGMP level of tissue and vascular AngⅡ release level are observed.Results Whole Wister rat's experiment results:In AngⅡ group,the aortic cGMP content is markedly elevated compared with group control(P
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Objective To probe into modulation effect between the EDRF/NO And ET.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic change of MABP,plasm ET-ir and cGMP level of tissue is observed.Results Whole Wister rat's experiment results:① In ET group,MABP first instantly(1~2min)reduces 6.58?0.67kPa,afterwards duratively enhances,it assumes the bidirectional response,when it reaches to 30min,MABP elevates 33.3?0.4kPa than before taking ET;Causes the aortic cGMP content to elevate,comparatively group control to increase 74.5%;② In L-NNA group,MABP slow rise,within 30min elevates to 4.62?2.04kPa;With control group comparison,the GMP level is reduced 5 times(0.42?0.08 versus the control 2.14?0.18pmol/mg Pr,P0.05);④ In Ach group,The vascular ET release reduces [406?31 versus control group 514?50pg/(g.w.w),P
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Objective To observe effect of large blood vessel hypoxia on the Wister rat′s NO activity. Methods Thoracic aorta rings model with full endothelium and removed endothelium of Wistar rat were prepared , hypoxia stimulated aorta rings and noted changes of constriction extent. Results Endothelium full , removed endothelium aorta rings by hypoxia contract extent difference was 598?42mg and 208?38mg, both had significance discrepancy (P0.05), and NTG made blood vessel contract to reduce range, reach 57.21% (P
RESUMO
Taking medical morality unrturance of systematicness and practicality,the medical workers and medical students should have a soberly and definitely understand,and hold idea to bringing society effect and basic request of medical morality,meaning of medical aim and peristing in making good morality,medical morality culture,and setting medical logos spirit and etc problems.It is a realism proposition for perspicuiting basic elements and inertia factors of medical logos spirit,and unity od medical ought and medical logos spirit.
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As part of medical scientific spirits and closely associated with medical ethics,medical rational spirit is the spiritual foundation of medical treatment activities and thus should evolve compatibly with medical science.Due to the specific characteristics of medical science,a noble and steady medical rational spirit is an important factor in accelerating harmonious medical consumption and basic request for the application of logic inevitability of medical purpose.
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The effect of GABA ergic system in the brain in mediating convulsions induced by quinolinic acid (QA) was studied. Muscimol,an agonist of GABAA-receptor, and aminooxyacetic acid (AOAA),an inhibitor of GABA transami-nase(GABA-T) ,and alprazolam which increased the affinity of GABA-receptor as it binds with benzodiazepine-receptor, were used to increase GABAergic function in the brain. Results showed that the above substances antagonized QA-induced convulsions. In contrast, bicu-culline,an antagonist of GABAA-receptor, and 3-mercaptopropionic acid (3-MP), an inhibitor of both GABA synthesis and its release, were used to decrease GABA ergic function in the CNS. They were found to potentiate QA-induced seizures. All these results suggest that GABA ergic system in brain plays an important role in modulating QA-induced convulsions.