RESUMO
Because of its relatively easy synthesis, chalcone skeleton has been as a point of interest for organic and medicinalchemists from research groups worldwide. Chalcone scaffold constitutes the core of some interesting biologicallyactive natural products. Chalcone derivatives are among feasible potent active agents, such as anticancer, antibacterial,antifungal, antileishmanial, antimalarial, and antiviral. Due to the knowledge of heterocyclic chemistry, recentlychalcones bearing heterocyclic moieties have been synthesized and biologically investigated for specific target ofdiseases. The current review focuses on the latest application of chalcones integrated with N, O, and S-heterocyclicsystem and their wide spectrum of biological performance during 10 years (2010–2019). The results reported inthe review indicate that many chalcone-heterocycle hybrids may be useful as future drug candidates due to theircomparable or higher activity than that of the standards.