PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c.

Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe PEFR, FEF25-75 and MVV and their relationship with HbA1c in type- 1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January and 31st December 2009. A total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as control. For assessment of lung function PEFR, FEF25-75 and MVV of all the subjects were measured by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated hemoglobin (HbA1c) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by unpaired‘t’ test and Pearson’s correlation coefficient test. Results: PEFR (p<0.001), FEF25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF25-75 (p>0.05), and MVV (p<0.05) were negatively correlated with HbA1c. Conclusion: The lung functions were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction is mainly due to poor glycemic control.

FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c.

Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to micro and macrovascular diseases which affect eyes, kidneys, heart, blood vessels, nerves and also lungs. There may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe FVC, FEV1, FEV1/FVC % and their relationship with HbA1C in type-1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from January to December 2009. A total number of 60 male subjects, from 18-30 years of age was taken and was divided into control and study groups. Among them study group was consisted of 30 type-1 diabetic male patients. Control group was consisted of 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic subjects. All the subjects belonged to lower socio-economic status. For assessment of lung function, FVC, FEV1, FEV1/FVC % of all the subjects were measured. All of theses tests were done by spirometric method by using a digital Spirometer. Again, to observe glycemic control of blood, glycosylated hemoglobin (HbA1c) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by Independent-Samples ‘t’ test and Pearson’s correlation coefficient test as applicable. Results: FVC (p <0.001), FEV1 (p < 0.001), and FEV1/FVC% (p < 0.05) were significantly lower in type- 1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again FVC and FEV1 had significant (p < 0.001) negative correlation but FEV1/FVC% had non-significant positive correlation with HbA1c. Conclusion: Impairment of some lung functions may be found in type-1 diabetic male which may be due to poor glycemic control.