RESUMO
Background: Transabdominal pre-peritoneal repair is a wellaccepted method of inguinal hernia repair involving bothoptions of fixation or non-fixation of mesh. Objective was toanalyse the comparison between mesh fixation versus nomesh fixation in laparoscopic inguinal hernia repair– TAPP, interms of: operative time, post-operative pain, length of hospitalstay and recurrence.Materials and Methods: This prospective randomised studywas conducted on a sample of 30 male patients whounderwent TAPP inguinal hernia repair. 15 of these underwentfixation and the remaining 15 with non-fixation of mesh.Results: Mesh fixation increases postoperative pain andoperative time. No difference observed in terms of hospital staybetween the 2 groups. Fixation doesn’t prevent recurrence.Conclusion: Mesh non -fixation can be utilised as a safe andeffective approach in TAPP hernia repair.
RESUMO
Background: Ventral hernia is defined as a fascial defectlocated to the abdominal wall. The laparoscopic repair ofIncisional and ventral hernia is fast becoming the standard ofcare.Objectives: To compare and evaluate the post-operative painand convalescence between two groups.Methods: Study was conducted on 30 cases of ventral herniaadmitted in Rajindra Hospital, Patiala. They were divided intotwo comparison groups (15 cases each). Group A: Openventral hernia repair; Group B: Laparoscopic ventral herniarepair.Results and Conclusions: Laparoscopic repair should be thepreferred method of repair of ventral hernia as it is associatedwith a shorter hospital stay, decreased post-operative pain,better cosmetic results decreased complication rate likerecurrence, and seroma formation, decreased mesh infectionrate, early ambulation period, better patient satisfaction andearly return to activities.
RESUMO
The success of anti-cancer drug targeting is depends on the ability of the therapeutics to reach their desirable cellular and intracellular sites and minimizing action at the nonspecific sites. In the present study, anti-human epidermal growth factor receptor (HER-2, ErbB2) antibody anchored nanoparticles were prepared and evaluated for the assessment of targeting potential in breast cancer cell. In an attempt for comparison of carrier system for site-selective delivery, docetaxel loaded PLGA nanoparticles, PLGA-PEG nanoparticles and PLGA-PEG immunonanoparticles capable of targeting breast cancer were prepared by emulsion solvent evaporation technique. The drug-loaded nanoparticles were characterized for their size and size distribution, surface charge, drug encapsulation efficiency and in vitro drug release. Our results demonstrate that docetaxel loaded PLGA-PEG immunonanoparticles strongly enhances the site specific uptake and high cytotoxic effect at targeted sites, as compared with PLGA, PLGA-PEG nanoparticles. In conclusion polymeric immunonanoparticles could be a promising carrier for the treatment of HER2-overexpressing breast cancers.