Invasive pulmonary aspergillosis in infancy: a rare presentation of chronic granulomatous disease

We report a rare case of chronic granulomatous disease in a three-month-old female infant who presented with a chest mass, and was found to have invasive pulmonary aspergillosis and rib osteomyelitis, which was confirmed by culture and histopathology. The diagnosis of chronic granulomatous disease in this patient was made by the Nitroblue Tetrazolium test. The patient was successfully treated with surgery and antifungal agents

Microbiological evaluation of urinary tract infection in children

To assess the microbiological pattern and the susceptibility of antibiotics in urinary tract infection [UTI]. Material and methods: A total of one hundred and ninety five children, aged one month to twelve years enrolled in the study were diagnosed to have UTI between September 2001 and November 2002 at Queen Alia Military Hospital. The diagnosis of UTI was based on clinical picture, urinalysis and urine culture. The methods of urine collection were clean catch specimens, supra pubic aspiration, trans urethral catheterization, bag collected specimens, or midstream specimen. All patients enrolled in the study had no anatomical or functional genitourinary abnormalities. Among the 195 patients who included in the study, 53 [27.2%] were males and 124 [72.8%] were females, the most encountered pathogens recovered were E Coli, Klebsiella, Proteus Mirabilis, and others [69.8%, 11.1%, 14.3%, 4.8%,] and [75%, 13.4%, 7.1%, 4.5%,] respectively in both sexes. E coli was the most commonly encountered pathogen [73.1%] Bacterial resistance to common antibiotics using the disc diffusion method showed resistance to Ampicillin [80%], Trimetheoprim [82%], Cephalexin [75%], Amoxillin-Clavulanate [22%], Nitrofurantoin [16%], Amikacin [10%], Cefataxime [9%], Nalidixic acid [16%]. This study shows decrease in bacterial susceptibility to common oral antibiotics. Empirical initial treatment with Trimethoprim and Cephlexin is inadequate. A large number of pathogens can be empirically treated with Amoxicillin- Ciavulauate and Nalidixic acid. It is thus mandatory to perform regular assessments of anti microbial sensitivity in the community