RESUMO
This study aimed to determine the relationship between lipid and apolipoprotein B-100 [apo B-100] levels in maternal and umbilical cord sera as well as the effects of these components on anthropometric measurements of newborn infants. This correlational study was performed on 85 appropriate for gestational age [AGA] newborns and their mothers. For analysis, 5 ml of maternal blood and 5 ml of umbilical venous cord blood were obtained during labor and immediately after delivery, respectively. Sera were separated by centrifugation and analyzed on the same day for estimation of lipid profile including total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and apolipoprotein B-100. Also, anthropometric indices of newborn infants were measured and recorded. Pearson's correlation coefficient was used to determine the relationship between variables. There was a positive correlation between maternal and neonatal serum TC levels [r=0.23, P=0.042]. Maternal LDL-C level was positively correlated with neonatal HDL-C [r=0.24, P=0.035], TC [r=0.29, P=0.01], and apolipoprotein B-100 levels [r=0.25, P=0.031]. A significant positive correlation was observed between maternal apolipoprotein B-100 level and neonatal TC [r=0.26, P=0.019], HDL-C [r=0.23, P=0.043], and apolipoprotein B-100 levels [r=0.24, P=0.038]. Maternal TG level was positively correlated with neonatal crown-heel length [r=0.27, P=0.018] and birth weight [r=0.23, P=0.039]. However, maternal HDL-C level was negatively correlated with neonatal birth weight [r=-0.29, P=0.01] and chest circumference [r=-0.27, P=0.019]. A significant negative correlation was found between cord blood TG level and newborn's head circumference [r=- 0.23 P=0.046]. Maternal lipid profile can affect neonatal lipid level and anthropometric measurements.
RESUMO
Controversial findings exist regarding the association between neonate gender and umbilical cord blood lipid levels. This study aims to compare the levels of lipids and lipoprotein B-100 in the umbilical cord blood of male and female newborns and assess the impact of these factors on neonatal anthropometric measurements. This cross-sectional study was performed on 75 healthy, term [34 male and 41 female] newborns. A total of 5 ml of umbilical cord blood was obtained immediately after delivery and analyzed on the same day to estimate lipid concentrations and apolipoprotein B-100. Additionally, we measured and recorded neonatal anthropometric indicators. The independent sample t-test was used for comparison of mean values in the two groups. The relationship of cord blood lipid profile with anthropometric data was assessed by the Pearson correlation test and multiple linear regression. The cord blood from female newborns had higher levels of low density lipoprotein- cholesterol [LDL-C], high density lipoprotein-cholesterol [HDL-C] and total cholesterol [TC] compared to male newborns, whereas levels of lipoprotein B-100 and triglyceride [TG] were higher in males compared to female newborns. These differences were not statistically significant. In female newborns there was a significant inverse correlation between TG level and head circumference [P=0.038]. In males, there was no statistically significant association between lipid levels and anthropometric parameters. Gender did not impact lipid and apolipoprotein B-100 levels in newborns. This study showed a significant inverse correlation between TG level and head circumference in female newborns.