RESUMO
Background: Nephrotic syndrome (NS) is more common in children in comparison of adults. Dyslipidaemia is considered one of the common findings of nephritic syndrome. C reactive protein (CRP) is considered one of the important marker of inflammation as well as cardiovascular disease. Therefore the present study was designed to assess if there is any relation between lipid profile, CRP and nephorotic syndrome. Methods: Present study included thirty (30) children suffering from nephritic syndrome and thirty (30) healthy children as from pediatric wards of Rajshree Medical Research Institute, Bareilly. All children with nephrotic syndrome and control group were between 2-12 years of age. Serum cholesterol level (normal range 150-200 mg/dl), triglycerides (normal range 60-165 mg/dl) and serum VLDL were measured by Enzymatic colorometric method. Whereas HDL (normal range 30-70 mg/dl) was measured by Phosphotungstate method. Serum LDL was calculated by Friedewald‟s equation. Serum Albumin (normal range 3.5-5 gm/dl) was measured by Photometric method. CRP was estimated by enzyme linked immune assay (ELISA) method. Results: TC (p<0.01), LDL (p<0.01) and TG (p<0.01) were significantly high in patients of nephrotic syndrome in comparison of control children. Further, HDL (p<0.01) was significantly low in nephrotic syndrome group in comparison of control group. Tthere was an insignificant difference in VLDL of both groups. There was an insignificant difference in CRP (p<0.07) of both groups. Conclusion: Findings of the current study suggest that dyslipidaemia is associated with nephritis syndrome. This high level of lipoprotein can lead to future cardiovascular diseases in nephrotic syndrome patients. Although, CRP level which is a strong predicator of CVD is normal; nevertheless, risk of future CVD cannot be ruled out. However, more studies on large populations are required to establish a relation between lipid profile, CRP and nephrotic syndrome.