Study of bone density ostocalcin level in children with acute lymphoblastic leukemia

Objective: To study Bone density and serum osteocalcin level in children with acute lymphoblastic leukemia

Methods: Serurn osteocalcin and DXA scan were evaluated in 45 children with ALL, 15 at diagnosis and before starting chemotherapy, 15 during chemotherapy and 15 after completing their treatment regimen

Results: From the total 45 patients, 23 [51.1%] had low osteocalcin level and 36 [80%] had low bone rnineral density [48% had osteopenia and 32% had osreoporosis]

Conclusion: Musculoskeletal abnormalities are present in children with ALL at diagnosis, during treatment] and persist as long-term squeal after treatment