RESUMO
Statement of the Problem: Neoadjuvant chemotherapy [NCH] is controversial in the treatment of oral squamous cell carcinoma [OSCC]
Purpose: The aim of this study was to evaluate the efficacy of NCH on OSCC prognosis
Materials and Method: In this retrospective cohort study, 94 patients were studied in two groups. The patients in group 1 received NCH before the surgery, and those in group 2 underwent resection without any chemotherapy prior to surgery. The employed NCH agents consisted of cisplatin in combination with 5-fluorouracil in two treatment courses. Tumor size, lymph node involvement, age, and follow-up time were considered as variable factors of the study. Local recurrence [LR] and distant metastasis [DM] were outcomes of the study
Results: Comparison of LR and DM in various tumor sizes demonstrated no significant difference between the two groups [p> 0.05]. Analysis of the data did not show any statistically significant difference between the groups for LR in subjects with N0, N1 and N2. Each one-year increase in age was associated with 10% increase in the hazard ratio [HR] [HR distance metastasis Y/N = 1.10, p= 0.05]. In the same analysis, when considering LR as a dependent factor, LR risk in N2 was 3 times more than in N1 [p= 0.02]. LR risk in N3 was 5 times more than in N1 [HR local recurrence [p= 0.006]
Conclusion: Based on our results, neoadjuvant chemotherapy with combination of cisplatin and 5-fluorouracil may not improve prognosis of OSCC. However, further studies are suggested to assess other neoadjuvant chemotherapy protocols in OSCC patients
RESUMO
This case report describes a 59-year-old woman with a giant basal cell carcinoma on the face neglected for 11 years. Surgical resection of the lesion resulted in a 13 × 11 cm defect. Issues regarding the adequately safe surgical margins and the management of the resultant defect through modern wound dressing technologies are discussed