RESUMO
A prospective study of adverse effects of 728 doses of diphtheria and tetanus toxoids and whole cell pertussis vaccine [DPT] was performed in 226 children observed longitudinally from 2 months to 18 months of age. Compliance for completing a clinical observation form in 48 hours following injections was > 99%. Fever, local reactions or adverse adverse behavioral effects were described in association with > 95% of DPT closes. No conclusion, hypotonic hyporesponsive episode, encephalopathy or temperature > 40.5C occurred. Local inflammatory effects occurred maximally in the first 6 hours following vaccine but fever peaked later. There was no interrelationship between occurrence of local reactions and fever. These data suggest that age of the infants has a major effect on the type and rate of adverse clinical events