Effects of short and long-term neuroleptic administration on brain bioamines

Effects of short and long term administration of Chlorpromazine and Fluphenazine on the levels of certain bioamines have been investigated in rabbit. Brain levels of 5-hydroxytryptamine, 5-hydroxyindole acetic acid and tryptophan remain unchanged after short term [90 mins.] administration of Chlorpromazine [10 mg/kg] and fluphenazine [2.5 mg/kg]. Although long term administration [21 days] of Chlorpromazine and Fluphenazine resulted in an increase in 5-HT and 5-HIAA level of mid-brain hypothalamus and other regions examined, these findings suggest that neuroleptics enhance the synthesis and utilization of brain serotonin