Efficacy and safety of metformin in over weight and obese patients with polycystic ovary syndrome

To evaluate the efficacy and safety of metformin in overweight and obese women with polycystic ovary syndrome. Forty-four overweight and obese female patients with diagnosed polycystic ovary syndrome were evaluated in an open label study. Patients were assigned metformin SOOmg thrice daily for six months. The primary outcomes were to assess change in the fasting serum insulin level, fasting plasma glucose, insulin sensitivity, weight, BMI, Waist to hip ratio and ultrasonographic features of overweight and obese women. The secondary outcomes were systolic and diastolic blood pressure, menstrual cyclicity and hirsutism. The safety of intervention was assessed by recording the self-reported adverse effects and performing renal and hepatic profiles. The patients were evaluated at monthly intervals. Forty subjects [90.9%] completed the study. At the end of six months, there was a significant effect of the drug on all the clinical parameters. Weight decreased from 85.71 +/- 1.04 to 84.38 +/- 1.02, BMI from 33.2 +/- 0.32 to 32.8 +/- 0.33[p <0.05] and Waist to hip ratio from 0.85 +/- 0.003 to 0.83 +/- 0.002.Ultrasonographic features, systolic and diastolic blood pressure also showed statistically significant improvement. Menstrual cyclicity, hirsutism, and metabolic parameters [serum fasting insulin level, fasting plasma glucose, HOMA index] also showed statistically significant improvement. The drug was well tolerated by the patients. No change was observed in blood urea, ALT and serum creatinine levels. Metformin is a safe and effective drug for the treatment of obese and over weight, women with PCOS

Study to assess the effect of topical clindamycin gel in acne vulgaris

Acne vulgaris is very common and all individuals of either sex suffer from this ailment at adolescent. The areas involved are cheeks, nose fore head, sometimes back also. Number of treatment options are available but clindamycin gel as topical preparation has been found effective. To find the suitability of clindamycin topically used. Study was performed on 40 patients of either sex, age group 14-29 years they were instructed to apply clindamycin topically twice daily up to three months. The results were significant at the end of treatment. The results were discussed with other studies. Clindamycin topical in the form of gel is suitable and effective for treatment of acne