overview of the most common enzyme defect, glucose-6-phosphate-dehydrogenase deficiency

Background: Glucose-6-Phosphate-Dehydrogenase [G6PD] deficiency is the most common enzyme deficiency globally and is more remarkable in certain parts of the world which had high malaria prevalence in the past. It is an X-linked genetically inherited disorder, where the first presentation can be neonatal jaundice. There are over 300 variants of this disorder based upon the genetics. Although the morbidity and mortality is not very high, the deficiency can be more appropriately managed by proper preventive methods which include screening and avoidance of trigger. Also prompt management of acute hemolysis can save a child from many complications

Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE from January 1987 to March 2017. The following search terms were used: G6PD deficiency, prevalence of G6PD, genetics of G6PD deficiency, management and diagnosis of G6PD

Aim of the work: this study aimed to understand about the etiology, pathophysiology and study various lines of prevention and management of G6PD deficiency in pediatric age group

Conclusion: proper preventive and treatment methods can avoid negative effects on the child's quality of life and reduce morbidity and mortality, therefore the child's care takers must be well informed

Anemia of chronic disease

Introduction: anemia of chronic disease has a widespread impact on patients with chronic disorders such as chronic inflammation, infection, malignancy etc. The pathophysiology behind it is largely due to involvement of hepcidin levels which are high as a result of the underlying chronic disorder, but negatively affects iron metabolism and erythropoiesis

Aim of the work: we tried to understand the pathogenesis, impact, diagnosis, and management of anemia due to chronic diseases

Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed and EMBASE from January 2001 to March 2017. The following search terms were used: anemia of chronic disease, anemia of inflammation, types of anemia, management of chronic anemia

Conclusion: since absolute treatment for the underlying chronic conditions are not available, various other modalities aimed at treating the anemia are developing. They include conventional and novel therapies. More researches must be done in order to manage the condition by treating the underlying cause, or for finding therapies with least side effects