Computer-guided buccal cortical plate separation for removal of calcified benign odontogenic tumors affecting the mandibular angle region / 대한악안면성형재건외과학회지

Purpose@#Surgical removal of intra-bony calcific benign lesions is technically challenging regarding its accessibility, proximity to vital structures, and deteriorating effect on the remaining bony structures. @*Methods@#Computer-guided buccal cortical plate separation was performed for ten patients using patient-specific osteotomy locating guides and pre-bent plates. The guide was designed to outline the osteotomy, the buccal cortical plate was separated, the lesion was removed, and finally, the pre-bent plates were used to fix the separated cortex. @*Results@#Surgical procedures were uneventful for all patients, operation time was 39.5 ± 13.01 min, postoperative pain decreased within the follow-up time intervals, and there was a statistical significant difference between the time intervals (P value < 0.001). Edema and trismus were acceptable. One case showed nerve affection which resolved after 4 weeks. @*Conclusion@#Computer-guided buccal cortical plate separation for removal of intra-bony calcified benign lesions provides a promising approach, especially for inexperienced surgeons.

Spectrophotometric determination of dextromethorphan hydrobromide in pure form and in pharmaceutical formulations

Simple, sensitive and accurate spectrophotometric method have been developed for the determination of dextromethorphan hydrobromide in pure form and in pharmaceutical formulations. This method are based on the formation of ion-associate complexes between the drug and phenol red [I], cresol red [II], methyl orange [III], congo red [IV] and EBT [V] in acidic medium. The complexes are extracted into chloroform and measured at 407, 424 and 497 for [I or II], [III] and [IV] respectively, or into methylene chloride at 520 nm for [V]. Beer's law is obeyed in the concentration ranges from 2.0-24, 2.0-26 and 2.0-20 micro g ml[-1] for [I or II], [III or IV] and [V], respectively. The stoichiometric ratio of the ion-associate complexes was established using the continuous variation method and found to be 1:1 for all reagents used. The validity was assessed by applying the standard addition technique. The results were compared statistically with the official method showing a good agreement with high precision and accuracy

Assessment of right ventricular function in patients with chronic pulmonary hypertension using tissue doppler imaging

Chronic pulmonary hypertension [CPHT] has a great impact on both right ventricular [RV] systolic and diastolic properties and the assessment of those properties is not always feasible by traditional echocardiography examination. Tissue Doppler imaging [TDI] has recently emerged as a new, rapid and noninvasive tool for evaluation of RV systolic function. To determine the right ventricular systolic and diastolic function in patients with chronic pulmonary hypertension by tissue Doppler imaging and its correlation to conventional echocardiography parameters. The study included 30 consecutive patients with symptoms of right-sided heart failure due to CPHT who were in sinus rhythm, together with 10 normal subjects as controls. Pulsed-wave tissue Doppler imaging was used to measure peak systolic tricuspid annular velocity [Sa] as an index of RV function, peak early [Ea] and late [Au] diastolic tricuspid annular velocities. Among the 30 patients, 18 were females [60%] and 12 were males [40%]. Their mean age was 47.0 +/- 7.5 years. Among the 10 control subjects, 5 were males [50%] and 5 were females [50%]. The mean Sa velocity of the patient group was lower than the control group [9.57 +/- 2.06 vs. 15.05 +/- 1.75 cm/s., p < 0.001] signifying impairment of RV systolic function. The mean Ea velocity and the Ea/Aa ratio of the patient group was lower than the control group [9.85 +/- 3.21 vs. 17.95 +/- 2.27 cm/s., p < 0.001 and 0.98 +/- 0.58 vs. 1,54 +/- 0.18, p < 0.05 respectively], while the mean Aa velocity did not show any significant difference between the two groups [11.94 +/- 5.25 vs. 11.67 +/- 1.31 cm/s., p = NS]. In the patient group, there was a very good inverse correlation between both right ventricular diastolic dimension, right ventricular systolic pressure and Sa velocity as an index of RV systolic function [r = - 0.79, p < 0.001, and r = - 0.57, p < 0.001, respectively]. There was a very good correlation between E/A ratio of the trans-tricuspid Doppler flow and Ea/Aa ratio measured by TDI of the tricuspid annular motion "indices of diastolic function" [r = 0.79, p <0.001]. TDI is a new noninvasive method to detect systolic and diastolic dysfunction in patients with chronic pulmonary hypertension