RESUMO
This study aimed to evaluate the LP-a and fibrinolytic parameters [plasminogen, fibrinogen and D-dimer] in normotensive and preeclamptic pregnant and non-pregnant women, as well as to assess any association with severity of the disease. The study was carried out in 52 women with age range 17-38 years, including 10 normotensive pregnant women, 31 preeclamptic women [13 with mild preeclampsia [MPE] and 19 with severe preeclampsia [SPE]] and 10 non-pregnant women, as control group. The mean gestational age for MPE, SPE and normotensive pregnant women were 35.5 +/- 3.1 and 36 +/- 1.4 weeks, respectively. In conclusion, LP[a] levels are elevated in preeclampsia and associated with severity of the disease. So, it may serve as a marker of the pathogenic process. Abnormalities in fibrinolytic parameters [fibrinogen and D-dimer] indicated activation of fibrinolysis in response to intravascular coagulation, which may be prevented from reaching its full potential. On the other hand, the absence of significant changes in plasminogen may not be mediated by tissue plasminogen activator [tPA], but by urokinase, whose interaction with PLG is not affected by Lp-a