Evaluation of hypoglycemic effect of Cassia Italica

Currently available treatment options fail to maintain glycemic control over long time and are accompanied by various side effects. Therefore, there is a need to develop newer treatment strategies such as hypoglycemic agents of plant origin as they are known to have fewer side effects. Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex. The study was conducted on 35 healthy rabbits of either sex following administration of Cassia italica plant extract for a period of 14 days. Present study provides evaluation of hypoglycemic effect of Cassia italica in the alloxan induced diabetes rabbits along with comparative hypoglycemic efficacy of glibenclamide. Results reveals that 100 mg/kg oral dose of plant extract did not cause significant changes in blood glucose level however results of plant extract at the dose of 200 mg/kg were similar to glibenclamide at the dose of 2.5mg/kg body weight, however result of the present study can only be confirmed after evaluating Cassia italica on large number of animals as well as clinically

Pharmacological activity of morpholino compound

The pharmacological effect of morpholino compound in different biological field is of great importance for researchers and investigators. They are working day and night to synthesize pharmacologically more effective morpholino derivatives with less toxic effects. This kind of pharmacological screening of synthesized compounds can lead to the discovery of biologically useful compounds. The findings of the present study are encouraging, since present compound showed a promising analgesic activities and anti-inflammatory. Chemically synthesized morpholino compound are tested for its analgesic and inflammatory activities in intact albino mice ad rat. Compound was administered orally in different doses using the tail immersion test in mice for analgesic activity. The results of this study demonstrated that compound has inhibitory effect on arachidonic acid metabolisms via cyclooxygenase pathway or we can say the inhibition of prostaglandins biosynthesis. Classical non-steroidal anti-inflammatory drug, which inhibits cyclooxygenase, can shift arachidonic metabolism to lipoxygenase products. These findings reflect a new fact of pharmacological action of this compound like inhibition of arachidonic acid pathway in vivo. It can be concluded that the present study revealed a fair success rate but it is necessary to carry out further investigation to confirm the results