Histopathological and histochemical lesions of hypothermia to what extent are these lesions reversible

Hypothermic injuries may have some forensic importance. Therefore, determination or exclusion of any slight organ injury caused by hypothermia can be of value in cases of compensation claims. Results revealed that hypothermic lesions of all internal organs [except the lung and heart] are reversible. Hypothermic residual lesion of the heart is myocardial fibrosis. Detection of residual lung lesion needs more prolonged duration of follow up to determine the possible sequelae of bronchopneumonia

Some effects of heated raid mat on albino rats

Forty adult albino rats were divided into four equal groups. Three groups were exposcd to heated Raid mat overnight [about 10 hours] daily for 4, 8, 12 weeks respectively, the fourth group was used as a control. At the end of the periods of exposure, blood was taken for haematological and enzymatic analysis, the liver was removed for histological and histochemical studies. It was found that the R B Cs count and HB% were statistically decreased while the total W B Cs count and lymphocytes were statistically increased, the serum enzymes [ALT, AST, AP] were statistically increased. These haematological and biochemical changes were time related with exposure. The histological and histochemical changes of the liver were more marked in the third group

Hepatotoxic effect of concomitant administration of acetaminophen [paracetamol] and ethanol in rats

Five groups of albino rats, 10 animals each, were used in this work. Animals of group I were given ethanol, those of group II were given acetaminophen, while in group III and IV animals were given both ethanol and acetaminophen concomitantly. The dose of acetaminophen was doubled to animals of group IV. The fifth group was served as a control. Histopathological and histochemical studies of the liver showed that the hepatotoxic effect of acetaminophen or ethanol when each was given alone is more than when both substances were given concomitantly

Effect of pretreatment with catapres [clonidine hydrochloride] and avil [pheneramine maleate] on acute dimethoate toxicity in rabbits

Twenty four male rabbits were used in this study, they were about 4 months oldand their weight ranged between 1.1-1.3 kg. They were divided into 4 equalgroups. Animals of the first group served as control, they were given 75mg/kg [1/4 LD50] of dimethoate orally. The other 3 groups receivedsubcutaneous pretreatment with clonidine [0.35 mg/kg], avil [15 mg/kg] andcombined clonidine and avil before giving dimethoate, respectively. Theeffects of pretreatment and dimethoate were assessed by serial measurements ofserum cholinesterase enzyme activity and observation of the physical signs. It was found that clonidine pretreatment has more protective effect againstacute dimethoate toxicity than that of avil. On the other hand, combinedclonidine and avil pretreatment produced more protective effect than occurredby single drug alone