Congenital morphological and skeletal abnormalities of cyproheptadine hydrochloride [periactin] in rats

Cyprotoheptadine hydrochloride [periactin] is one of the antihistaminic drugs which are widely used and frequently described. The aim of this work is to evaluate and find out the effects of periactin on the offsprings of the pregnant rats. It is given orally in a dose of 1.8 mg/kgm to pregnant rats which are divided into 3 groups according to the period of pregnancy. Several morphological and skeletal abnormalities are observed among the offspring. It can be concluded that periactin is a dangerous antihistaminic on the off springs of the rats, hence it is better to be avoided at any time during pregnancy

Histological changes of some internal organs in offsprings of the rats treated with some antihistamines during pregnancy

Antihistamines can pass the placental barrier exposing the foetus to various hazards. This work was done to study the histopathological effects of some antihistamines on the offsprings of the rats. Tavegyl, Avil, and Periactin were given to 3 groups of animals before and during pregnancy. Drugs were given orally in doses of 0.18 mg, 3.6 mg, and 1.8 mg per kilogram body weight respectively. Histopathological study of the liver, kidney and lungs of the offsprings was done. In Tavegyl group, no histopathological changes could be detected, in Avil group, only the lungs showed some changes while in periactin group, several histopathological changes were noticed in the liver, kidney and lungs