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Objective To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CCl
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OBJECTIVE@#To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CCl-induced oxidative damage in rats.@*METHODS@#Hepatotoxicity was induced in albino Wistar rats by single dose of CCl dissolved in olive oil (1 mL/kg BW, 1/1 in olive oil, i.p.). Aqueous extract of J. phoenicea berries (AEJP) was administered at the dose of 250 mg/kg/day by gavage for 12 days.@*RESULTS@#Obtained results revealed that administration of CCl caused a significant increase in plasma ASAT, ALAT, ALP and LDH activities and total bilirubin concentration, compared to the control group. While, albumin and total protein concentration were significantly lower. Additionally, a significant decrease in the level of hepatic GSH, GPx and GST activities associated with a significant increase of MDA content in CCl group than those of the control. However, the treatment of experimental rats with AEJP prevented these alterations and maintained the antioxidant status. The histopathological observations supported the biochemical evidences of hepatoprotection.@*CONCLUSIONS@#The results of the present investigation indicate that J. Phoenicea possesses hepatoprotective activity and this effect was may be due to its antioxidant properties.
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The essential oil (EO) of Cotula cinerea Del collected in the region of Oued Souf (South-eastern Algeria) during two stages (flowering and fruiting), gave a performance that are 0.0801% ± 0.0117% at the flowering stage; and 0.391% ± 0.0664% at the fruiting stage. The chemical study of the (EO) of C. cinerea Del, analyzed by GCMS, showed the presence of 22 chemical compounds in the flowering period with the dominance of: 3-Carène (30.99%), Thujone (21.73%), Santolina triene (18.58%) and Camphor (6.21%). While 21 chemical compounds were obtained during the fruiting period with the dominance: Thujone (28.78%), 3-Carène (15.90%), Eucalyptol (15.13%), Santolina triene (13.38%) and Camphor (7.49%).Viewpoint chemical kinetics and composition, it was noticed that during the flowering stage the plant has produced eight compounds that are absent during the fruiting period. While seven other compounds appeared only during fruiting. It appears the antibacterial of (EO) has C. cinerea Del The sensitivity of the bacterial strains tested ; And E. faecium, E.coli, M. morganii, P. vulgaris, S. aureus and A. baumannii has shown great sensitivity; the strain P. aeruginosa have shown stiff resistance with every concentrations of (EO). As we did not notice any differences significant in the diameters of inhibition with all strains in two stages of growth.