RESUMO
En individuos con malnutrición por exceso, tanto la resistencia a la insulina como la hipertensión arterial se asocian al desarrollo de enfermedades cardiovasculares y un mayor riesgo de mortalidad. Desde el punto de vista nutricional, la alimentación en tiempo restringido (ATR) emerge como una intervención dietoterapéutica que puede contribuir a contrarrestar las consecuencias de la malnutrición por exceso. La siguiente revisión describe el efecto de la aplicación de la ATR sobre la resistencia a la insulina y presión arterial elevada. Finalmente, se abordan otros factores que subyacen a los efectos cardiometabólicos y consideraciones prácticas.
In obesity, insulin resistance and arterial hypertension are associated with the development of cardiovascular diseases and increased mortality risk. Time Restricted Feeding (TRF) has emerged as a dietary intervention that can help counteract the consequences of obesity. In the present review, we analyze TRF effects and its application on insulin resistance and high blood pressure. Finally, we discuss other factors underlying cardiometabolic effects and provide practical considerations.
RESUMO
One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.